Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

IFN-γ release assays [e.g., QuantiFERON (QFT)] are widely used for diagnosis of Mycobacterium tuberculosis (Mtb) infection. T-cell responses against QFT antigens ESAT6 and CFP10 are highly Mtb specific but previous studies indicated suboptimal assay sensitivity. Especially for potentially infected h...

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Detalles Bibliográficos
Autores principales: Adankwah, Ernest, Lundtoft, Christian, Güler, Alptekin, Franken, Kees L. M. C., Ottenhoff, Tom H. M., Mayatepek, Ertan, Owusu-Dabo, Ellis, Phillips, Richard Odame, Nausch, Norman, Jacobsen, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616195/
https://www.ncbi.nlm.nih.gov/pubmed/31333654
http://dx.doi.org/10.3389/fimmu.2019.01518

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