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Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration

BACKGROUND AND OBJECTIVES: The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by altering the activity of cytochrome P450 (CYP) isoenzymes. Tramadol is a commonly used analgesic metabolised mainly via CY...

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Detalles Bibliográficos
Autores principales:	Porażka, Joanna, Szałek, Edyta, Połom, Wojciech, Czajkowski, Mateusz, Grabowski, Tomasz, Matuszewski, Marcin, Grześkowiak, Edmund
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616205/ https://www.ncbi.nlm.nih.gov/pubmed/30778911 http://dx.doi.org/10.1007/s13318-019-00543-1

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