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Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people

OBJECTIVE: Cognitive impairment subjects exhibit high cortisol levels that are associated with low brain activity, but negative emotions with high cortisol are associated with high brain activity and reduced cognition. Emotion regulation, glucocorticoid hormones, and brain activity all interact with...

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Autores principales: Sroykham, Watchara, Wongsawat, Yodchanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616250/
https://www.ncbi.nlm.nih.gov/pubmed/31261527
http://dx.doi.org/10.1097/MD.0000000000016114
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author Sroykham, Watchara
Wongsawat, Yodchanan
author_facet Sroykham, Watchara
Wongsawat, Yodchanan
author_sort Sroykham, Watchara
collection PubMed
description OBJECTIVE: Cognitive impairment subjects exhibit high cortisol levels that are associated with low brain activity, but negative emotions with high cortisol are associated with high brain activity and reduced cognition. Emotion regulation, glucocorticoid hormones, and brain activity all interact with cognitive impairment. Therefore, we aimed to investigate cognitive impairment differences related to sex, morning salivary cortisol, emotion regulation, and brain activity in elderly people. METHODS: A total of 64 participants (19 males and 45 females) were tested by the Montreal cognitive assessment. Next, morning saliva was collected from each participant and analyzed by enzyme-linked immunosorbent assay, and the brain activity of the participants was subsequently recorded. Finally, emotion regulation was assessed via the Brunel mood scale questionnaire. RESULTS: The results revealed that attention was significantly lower in elderly females than in elderly males. Depression and vigor were significantly higher in elderly females than in elderly males. Brain activity of the slow (delta and theta) and fast (beta and high beta) waves was significantly higher in elderly females than in elderly males. Moreover, attention was negatively correlated with the theta wave, whereas delayed recall was positively correlated with the theta wave and salivary cortisol. Depression was positively correlated with the high beta wave and language skill, whereas the high beta wave was negatively correlated with visuoconstructional skill. CONCLUSION: The brain activity, emotion, and cortisol were influenced by cognitive impairments, although the relation of brain activity with glucocorticoid hormones remains inconclusive. This finding may be useful to the brain aging process, promote healthy brain aging, and prevent neurodegenerative conditions.
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spelling pubmed-66162502019-07-22 Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people Sroykham, Watchara Wongsawat, Yodchanan Medicine (Baltimore) Research Article OBJECTIVE: Cognitive impairment subjects exhibit high cortisol levels that are associated with low brain activity, but negative emotions with high cortisol are associated with high brain activity and reduced cognition. Emotion regulation, glucocorticoid hormones, and brain activity all interact with cognitive impairment. Therefore, we aimed to investigate cognitive impairment differences related to sex, morning salivary cortisol, emotion regulation, and brain activity in elderly people. METHODS: A total of 64 participants (19 males and 45 females) were tested by the Montreal cognitive assessment. Next, morning saliva was collected from each participant and analyzed by enzyme-linked immunosorbent assay, and the brain activity of the participants was subsequently recorded. Finally, emotion regulation was assessed via the Brunel mood scale questionnaire. RESULTS: The results revealed that attention was significantly lower in elderly females than in elderly males. Depression and vigor were significantly higher in elderly females than in elderly males. Brain activity of the slow (delta and theta) and fast (beta and high beta) waves was significantly higher in elderly females than in elderly males. Moreover, attention was negatively correlated with the theta wave, whereas delayed recall was positively correlated with the theta wave and salivary cortisol. Depression was positively correlated with the high beta wave and language skill, whereas the high beta wave was negatively correlated with visuoconstructional skill. CONCLUSION: The brain activity, emotion, and cortisol were influenced by cognitive impairments, although the relation of brain activity with glucocorticoid hormones remains inconclusive. This finding may be useful to the brain aging process, promote healthy brain aging, and prevent neurodegenerative conditions. Wolters Kluwer Health 2019-06-28 /pmc/articles/PMC6616250/ /pubmed/31261527 http://dx.doi.org/10.1097/MD.0000000000016114 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Sroykham, Watchara
Wongsawat, Yodchanan
Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title_full Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title_fullStr Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title_full_unstemmed Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title_short Effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
title_sort effects of brain activity, morning salivary cortisol, and emotion regulation on cognitive impairment in elderly people
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616250/
https://www.ncbi.nlm.nih.gov/pubmed/31261527
http://dx.doi.org/10.1097/MD.0000000000016114
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