Cargando…

Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation

Alzheimer’s disease (AD) is the most widespread form of dementia, affecting about 45 million people worldwide. Although the β-amyloid peptide (Aβ) remains the most acknowledged culprit of AD, the multiple failures of Aβ-centric therapies call for alternative therapeutic approaches. Conceivably, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balducci, Claudia, Forloni, Gianluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616274/ https://www.ncbi.nlm.nih.gov/pubmed/31333460 http://dx.doi.org/10.3389/fphar.2019.00738

Ejemplares similares

Alzheimer’s Disease, Oligomers, and Inflammation
por: Forloni, Gianluigi, et al.
Publicado: (2018)

Neuroinflammation and the Gut Microbiota: Possible Alternative Therapeutic Targets to Counteract Alzheimer’s Disease?
por: Cerovic, Milica, et al.
Publicado: (2019)

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers
por: Stravalaci, Matteo, et al.
Publicado: (2016)

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo
por: Fluharty, Brian R., et al.
Publicado: (2013)

Amyloid β-protein oligomers and Alzheimer’s disease
por: Hayden, Eric Y, et al.
Publicado: (2013)

β-Amyloid oligomers in aging and Alzheimer’s disease
por: Zahs, Kathleen R., et al.
Publicado: (2013)

Anti-inflammatory Activity of a Polypeptide Fraction From Achyranthes bidentate in Amyloid β Oligomers Induced Model of Alzheimer’s Disease
por: Ge, Xiangyu, et al.
Publicado: (2021)

Oligomers and Neurodegeneration: New Evidence
por: Forloni, Gianluigi
Publicado: (2023)

Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington’s Disease
por: Paldino, Emanuela, et al.
Publicado: (2019)

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
por: Chen, Shi-Yu, et al.
Publicado: (2020)

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
por: Sun, Xiaojuan, et al.
Publicado: (2015)

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease
por: Mroczko, Barbara, et al.
Publicado: (2018)

Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β(1–42) Oligomers
por: Wang, Li-Sha, et al.
Publicado: (2019)

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease
por: Dinamarca, Margarita C., et al.
Publicado: (2012)

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease
por: Hölttä, Mikko, et al.
Publicado: (2013)

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
por: Ferreira, Sergio T., et al.
Publicado: (2015)

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease
por: Hector, Audrey, et al.
Publicado: (2021)

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
por: Belo, Rita F., et al.
Publicado: (2020)

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease
por: Wang, Nanbu, et al.
Publicado: (2020)

The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology
por: Salminen, Antero, et al.
Publicado: (2008)

Sleep and β-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments
por: Cordone, Susanna, et al.
Publicado: (2019)

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid
por: Herskovits, Adrianna Z., et al.
Publicado: (2013)

Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer's disease
por: Jebelli, Joseph D., et al.
Publicado: (2015)

Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease
por: Serra-Batiste, Montserrat, et al.
Publicado: (2018)

The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease
por: Viola, Kirsten L., et al.
Publicado: (2022)

ACU193: An Immunotherapeutic Poised to Test the Amyloid β Oligomer Hypothesis of Alzheimer’s Disease
por: Krafft, Grant A., et al.
Publicado: (2022)

Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease
por: Rosenberry, Terrone L., et al.
Publicado: (2022)

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes
por: Steardo, Luca, et al.
Publicado: (2015)

Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
por: Wang, Ya, et al.
Publicado: (2020)

Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile
por: Liu, Peng, et al.
Publicado: (2015)

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease
por: Liu, Zun-Jing, et al.
Publicado: (2016)

A Computational Exploration of the Molecular Network Associated to Neuroinflammation in Alzheimer’s Disease
por: El Idrissi, Fatima, et al.
Publicado: (2021)

Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-β story
por: Imbimbo, Bruno P., et al.
Publicado: (2022)

Breaking the Code of Amyloid-β Oligomers
por: Lesné, Sylvain E.
Publicado: (2013)

The Toxicity and Polymorphism of β-Amyloid Oligomers
por: Huang, Ya-ru, et al.
Publicado: (2020)

Editorial: Beta-Amyloid oligomer specific treatments for Alzheimer's disease
por: Hillen, Heinz
Publicado: (2023)

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates
por: Yue, Feng, et al.
Publicado: (2021)

Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets
por: Wong-Guerra, Maylin, et al.
Publicado: (2023)

Alzheimer’s disease: from basic science to precision medicine approach
por: Forloni, Gianluigi
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tp46espth3mijohg5ktf87l2cs