Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation

Neutrophil serine proteases (NSPs), like proteinase 3 (PR3) and neutrophil elastase (NE) are implicated in ischemia-reperfusion responses after lung transplantation (LTx). Cathepsin C (CatC) acts as the key regulator of NSP maturation during biosynthesis. We hypothesized that CatC inhibitors would r...

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Detalles Bibliográficos
Autores principales: Rehm, Salome R. T., Smirnova, Natalia F., Morrone, Carmela, Götzfried, Jessica, Feuchtinger, Annette, Pedersen, John, Korkmaz, Brice, Yildirim, Ali Önder, Jenne, Dieter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616352/
https://www.ncbi.nlm.nih.gov/pubmed/31289357
http://dx.doi.org/10.1038/s41598-019-46206-8

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