Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome

Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world’s oceans and are responsible for 20–25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthet...

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Autores principales: Di Dato, Valeria, Di Costanzo, Federica, Barbarinaldi, Roberta, Perna, Anna, Ianora, Adrianna, Romano, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616357/
https://www.ncbi.nlm.nih.gov/pubmed/31289324
http://dx.doi.org/10.1038/s41598-019-46276-8
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author Di Dato, Valeria
Di Costanzo, Federica
Barbarinaldi, Roberta
Perna, Anna
Ianora, Adrianna
Romano, Giovanna
author_facet Di Dato, Valeria
Di Costanzo, Federica
Barbarinaldi, Roberta
Perna, Anna
Ianora, Adrianna
Romano, Giovanna
author_sort Di Dato, Valeria
collection PubMed
description Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world’s oceans and are responsible for 20–25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthetic pathways that potentially lead to the synthesis of interesting secondary metabolites with pharmaceutical applications such as polyketides, prostaglandins and secologanin. We also show that these pathways are differentially expressed in conditions of silica depletion in comparison with standard growth conditions.
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spelling pubmed-66163572019-07-18 Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome Di Dato, Valeria Di Costanzo, Federica Barbarinaldi, Roberta Perna, Anna Ianora, Adrianna Romano, Giovanna Sci Rep Article Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world’s oceans and are responsible for 20–25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthetic pathways that potentially lead to the synthesis of interesting secondary metabolites with pharmaceutical applications such as polyketides, prostaglandins and secologanin. We also show that these pathways are differentially expressed in conditions of silica depletion in comparison with standard growth conditions. Nature Publishing Group UK 2019-07-09 /pmc/articles/PMC6616357/ /pubmed/31289324 http://dx.doi.org/10.1038/s41598-019-46276-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Di Dato, Valeria
Di Costanzo, Federica
Barbarinaldi, Roberta
Perna, Anna
Ianora, Adrianna
Romano, Giovanna
Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title_full Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title_fullStr Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title_full_unstemmed Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title_short Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
title_sort unveiling the presence of biosynthetic pathways for bioactive compounds in the thalassiosira rotula transcriptome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616357/
https://www.ncbi.nlm.nih.gov/pubmed/31289324
http://dx.doi.org/10.1038/s41598-019-46276-8
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