Cargando…

Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents

The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Assis, M., Robeldo, T., Foggi, C. C., Kubo, A. M., Mínguez-Vega, G., Condoncillo, E., Beltran-Mir, H., Torres-Mendieta, R., Andrés, J., Oliva, M., Vergani, C. E., Barbugli, P. A., Camargo, E. R., Borra, R. C., Longo, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616383/
https://www.ncbi.nlm.nih.gov/pubmed/31289314
http://dx.doi.org/10.1038/s41598-019-46159-y
_version_ 1783433495321772032
author Assis, M.
Robeldo, T.
Foggi, C. C.
Kubo, A. M.
Mínguez-Vega, G.
Condoncillo, E.
Beltran-Mir, H.
Torres-Mendieta, R.
Andrés, J.
Oliva, M.
Vergani, C. E.
Barbugli, P. A.
Camargo, E. R.
Borra, R. C.
Longo, E.
author_facet Assis, M.
Robeldo, T.
Foggi, C. C.
Kubo, A. M.
Mínguez-Vega, G.
Condoncillo, E.
Beltran-Mir, H.
Torres-Mendieta, R.
Andrés, J.
Oliva, M.
Vergani, C. E.
Barbugli, P. A.
Camargo, E. R.
Borra, R. C.
Longo, E.
author_sort Assis, M.
collection PubMed
description The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag(2)WO(4), irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag(2)WO(4) composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag(2)WO(4) perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected.
format Online
Article
Text
id pubmed-6616383
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-66163832019-07-18 Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents Assis, M. Robeldo, T. Foggi, C. C. Kubo, A. M. Mínguez-Vega, G. Condoncillo, E. Beltran-Mir, H. Torres-Mendieta, R. Andrés, J. Oliva, M. Vergani, C. E. Barbugli, P. A. Camargo, E. R. Borra, R. C. Longo, E. Sci Rep Article The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag(2)WO(4), irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag(2)WO(4) composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag(2)WO(4) perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected. Nature Publishing Group UK 2019-07-09 /pmc/articles/PMC6616383/ /pubmed/31289314 http://dx.doi.org/10.1038/s41598-019-46159-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Assis, M.
Robeldo, T.
Foggi, C. C.
Kubo, A. M.
Mínguez-Vega, G.
Condoncillo, E.
Beltran-Mir, H.
Torres-Mendieta, R.
Andrés, J.
Oliva, M.
Vergani, C. E.
Barbugli, P. A.
Camargo, E. R.
Borra, R. C.
Longo, E.
Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title_full Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title_fullStr Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title_full_unstemmed Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title_short Ag Nanoparticles/α-Ag(2)WO(4) Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
title_sort ag nanoparticles/α-ag(2)wo(4) composite formed by electron beam and femtosecond irradiation as potent antifungal and antitumor agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616383/
https://www.ncbi.nlm.nih.gov/pubmed/31289314
http://dx.doi.org/10.1038/s41598-019-46159-y
work_keys_str_mv AT assism agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT robeldot agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT foggicc agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT kuboam agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT minguezvegag agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT condoncilloe agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT beltranmirh agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT torresmendietar agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT andresj agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT olivam agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT verganice agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT barbuglipa agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT camargoer agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT borrarc agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents
AT longoe agnanoparticlesaag2wo4compositeformedbyelectronbeamandfemtosecondirradiationaspotentantifungalandantitumoragents