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Endophytic Fungi from Terminalia Species: A Comprehensive Review

Endophytic fungi have proven their usefulness for drug discovery, as suggested by the structural complexity and chemical diversity of their secondary metabolites. The diversity and biological activities of endophytic fungi from the Terminalia species have been reported. Therefore, we set out to disc...

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Autores principales: Kouipou Toghueo, Rufin Marie, Boyom, Fabrice Fekam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616413/
https://www.ncbi.nlm.nih.gov/pubmed/31137730
http://dx.doi.org/10.3390/jof5020043
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author Kouipou Toghueo, Rufin Marie
Boyom, Fabrice Fekam
author_facet Kouipou Toghueo, Rufin Marie
Boyom, Fabrice Fekam
author_sort Kouipou Toghueo, Rufin Marie
collection PubMed
description Endophytic fungi have proven their usefulness for drug discovery, as suggested by the structural complexity and chemical diversity of their secondary metabolites. The diversity and biological activities of endophytic fungi from the Terminalia species have been reported. Therefore, we set out to discuss the influence of seasons, locations, and even the plant species on the diversity of endophytic fungi, as well as their biological activities and secondary metabolites isolated from potent strains. Our investigation reveals that among the 200–250 Terminalia species reported, only thirteen species have been studied so far for their endophytic fungi content. Overall, more than 47 fungi genera have been reported from the Terminalia species, and metabolites produced by some of these fungi exhibited diverse biological activities including antimicrobial, antioxidant, antimalarial, anti-inflammatory, anti-hypercholesterolemic, anticancer, and biocontrol varieties. Moreover, more than 40 compounds with eighteen newly described secondary metabolites were reported; among these, metabolites are the well-known anticancer drugs, a group that includes taxol, antioxidant compounds, isopestacin, and pestacin. This summary of data illustrates the considerable diversity and biological potential of fungal endophytes of the Terminalia species and gives insight into important findings while paving the way for future investigations.
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spelling pubmed-66164132019-07-18 Endophytic Fungi from Terminalia Species: A Comprehensive Review Kouipou Toghueo, Rufin Marie Boyom, Fabrice Fekam J Fungi (Basel) Review Endophytic fungi have proven their usefulness for drug discovery, as suggested by the structural complexity and chemical diversity of their secondary metabolites. The diversity and biological activities of endophytic fungi from the Terminalia species have been reported. Therefore, we set out to discuss the influence of seasons, locations, and even the plant species on the diversity of endophytic fungi, as well as their biological activities and secondary metabolites isolated from potent strains. Our investigation reveals that among the 200–250 Terminalia species reported, only thirteen species have been studied so far for their endophytic fungi content. Overall, more than 47 fungi genera have been reported from the Terminalia species, and metabolites produced by some of these fungi exhibited diverse biological activities including antimicrobial, antioxidant, antimalarial, anti-inflammatory, anti-hypercholesterolemic, anticancer, and biocontrol varieties. Moreover, more than 40 compounds with eighteen newly described secondary metabolites were reported; among these, metabolites are the well-known anticancer drugs, a group that includes taxol, antioxidant compounds, isopestacin, and pestacin. This summary of data illustrates the considerable diversity and biological potential of fungal endophytes of the Terminalia species and gives insight into important findings while paving the way for future investigations. MDPI 2019-05-24 /pmc/articles/PMC6616413/ /pubmed/31137730 http://dx.doi.org/10.3390/jof5020043 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kouipou Toghueo, Rufin Marie
Boyom, Fabrice Fekam
Endophytic Fungi from Terminalia Species: A Comprehensive Review
title Endophytic Fungi from Terminalia Species: A Comprehensive Review
title_full Endophytic Fungi from Terminalia Species: A Comprehensive Review
title_fullStr Endophytic Fungi from Terminalia Species: A Comprehensive Review
title_full_unstemmed Endophytic Fungi from Terminalia Species: A Comprehensive Review
title_short Endophytic Fungi from Terminalia Species: A Comprehensive Review
title_sort endophytic fungi from terminalia species: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616413/
https://www.ncbi.nlm.nih.gov/pubmed/31137730
http://dx.doi.org/10.3390/jof5020043
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