FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter

FoxM1 amplification in human pancreatic cancer predicts poor prognosis and resistance to paclitaxel. Here, a novel role between FoxM1 (FoxM1b and FoxM1c) and Prohibitin1 (PHB1) in paclitaxel resistance has been identified. We adopted a bioinformatics approach to predict the potential effector of Fox...

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Detalles Bibliográficos
Autores principales: Huang, Chao, Zhang, Xin, Jiang, Li, Zhang, Limin, Xiang, Ming, Ren, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616481/
https://www.ncbi.nlm.nih.gov/pubmed/31334335
http://dx.doi.org/10.1016/j.omto.2019.05.005

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