Snail1: A Transcriptional Factor Controlled at Multiple Levels

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific...

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Detalles Bibliográficos
Autores principales: Baulida, Josep, Díaz, Víctor M., García de Herreros, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616578/
https://www.ncbi.nlm.nih.gov/pubmed/31141910
http://dx.doi.org/10.3390/jcm8060757
Descripción
Sumario:Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.

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