Snail1: A Transcriptional Factor Controlled at Multiple Levels

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific...

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Detalles Bibliográficos
Autores principales: Baulida, Josep, Díaz, Víctor M., García de Herreros, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616578/
https://www.ncbi.nlm.nih.gov/pubmed/31141910
http://dx.doi.org/10.3390/jcm8060757
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author Baulida, Josep
Díaz, Víctor M.
García de Herreros, Antonio
author_facet Baulida, Josep
Díaz, Víctor M.
García de Herreros, Antonio
author_sort Baulida, Josep
collection PubMed
description Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.
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spelling pubmed-66165782019-07-18 Snail1: A Transcriptional Factor Controlled at Multiple Levels Baulida, Josep Díaz, Víctor M. García de Herreros, Antonio J Clin Med Review Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator. MDPI 2019-05-28 /pmc/articles/PMC6616578/ /pubmed/31141910 http://dx.doi.org/10.3390/jcm8060757 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baulida, Josep
Díaz, Víctor M.
García de Herreros, Antonio
Snail1: A Transcriptional Factor Controlled at Multiple Levels
title Snail1: A Transcriptional Factor Controlled at Multiple Levels
title_full Snail1: A Transcriptional Factor Controlled at Multiple Levels
title_fullStr Snail1: A Transcriptional Factor Controlled at Multiple Levels
title_full_unstemmed Snail1: A Transcriptional Factor Controlled at Multiple Levels
title_short Snail1: A Transcriptional Factor Controlled at Multiple Levels
title_sort snail1: a transcriptional factor controlled at multiple levels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616578/
https://www.ncbi.nlm.nih.gov/pubmed/31141910
http://dx.doi.org/10.3390/jcm8060757
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