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Post-Infectious Myocardial Infarction: New Insights for Improved Screening
Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616657/ https://www.ncbi.nlm.nih.gov/pubmed/31212586 http://dx.doi.org/10.3390/jcm8060827 |
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author | Putot, Alain Chague, Frédéric Manckoundia, Patrick Cottin, Yves Zeller, Marianne |
author_facet | Putot, Alain Chague, Frédéric Manckoundia, Patrick Cottin, Yves Zeller, Marianne |
author_sort | Putot, Alain |
collection | PubMed |
description | Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious MI was defined by a concurrent diagnosis of acute infection at admission. Type 1 MI (acute plaque disruption) or Type 2 MI (imbalance in oxygen supply/demand) were adjudicated according to the universal definition of MI. From the 4573 patients admitted for acute MI, 466 (10%) had a concurrent acute infection (median age 78 (66–85) y, 60% male), of whom 313 (67%) had a respiratory tract infection. Type 2 MI was identified in 72% of post-infectious MI. Compared with other MI, post-infectious MI had a worse in-hospital outcome (11 vs. 6% mortality, p < 0.01), mostly from cardiovascular causes. After adjusting for confounders, acute infections were no more associated with mortality (odds ratio 0.72; 95% confidence interval 0.43–1.20). In the group of post-infectious MI, Type 1 MI and respiratory tract infection were associated with a worse prognosis (respective odds ratio 2.44; 95% confidence interval: 1.12–5.29, and 2.89; 1.19–6.99). In this large MI survey, post-infectious MI was common, accounting for 10% of all MI, and doubled in-hospital mortality. Respiratory tract infection and Type 1 post-infectious MI were associated with a worse prognosis. |
format | Online Article Text |
id | pubmed-6616657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66166572019-07-18 Post-Infectious Myocardial Infarction: New Insights for Improved Screening Putot, Alain Chague, Frédéric Manckoundia, Patrick Cottin, Yves Zeller, Marianne J Clin Med Article Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious MI was defined by a concurrent diagnosis of acute infection at admission. Type 1 MI (acute plaque disruption) or Type 2 MI (imbalance in oxygen supply/demand) were adjudicated according to the universal definition of MI. From the 4573 patients admitted for acute MI, 466 (10%) had a concurrent acute infection (median age 78 (66–85) y, 60% male), of whom 313 (67%) had a respiratory tract infection. Type 2 MI was identified in 72% of post-infectious MI. Compared with other MI, post-infectious MI had a worse in-hospital outcome (11 vs. 6% mortality, p < 0.01), mostly from cardiovascular causes. After adjusting for confounders, acute infections were no more associated with mortality (odds ratio 0.72; 95% confidence interval 0.43–1.20). In the group of post-infectious MI, Type 1 MI and respiratory tract infection were associated with a worse prognosis (respective odds ratio 2.44; 95% confidence interval: 1.12–5.29, and 2.89; 1.19–6.99). In this large MI survey, post-infectious MI was common, accounting for 10% of all MI, and doubled in-hospital mortality. Respiratory tract infection and Type 1 post-infectious MI were associated with a worse prognosis. MDPI 2019-06-11 /pmc/articles/PMC6616657/ /pubmed/31212586 http://dx.doi.org/10.3390/jcm8060827 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Putot, Alain Chague, Frédéric Manckoundia, Patrick Cottin, Yves Zeller, Marianne Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title | Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title_full | Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title_fullStr | Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title_full_unstemmed | Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title_short | Post-Infectious Myocardial Infarction: New Insights for Improved Screening |
title_sort | post-infectious myocardial infarction: new insights for improved screening |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616657/ https://www.ncbi.nlm.nih.gov/pubmed/31212586 http://dx.doi.org/10.3390/jcm8060827 |
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