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Post-Infectious Myocardial Infarction: New Insights for Improved Screening

Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious...

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Autores principales: Putot, Alain, Chague, Frédéric, Manckoundia, Patrick, Cottin, Yves, Zeller, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616657/
https://www.ncbi.nlm.nih.gov/pubmed/31212586
http://dx.doi.org/10.3390/jcm8060827
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author Putot, Alain
Chague, Frédéric
Manckoundia, Patrick
Cottin, Yves
Zeller, Marianne
author_facet Putot, Alain
Chague, Frédéric
Manckoundia, Patrick
Cottin, Yves
Zeller, Marianne
author_sort Putot, Alain
collection PubMed
description Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious MI was defined by a concurrent diagnosis of acute infection at admission. Type 1 MI (acute plaque disruption) or Type 2 MI (imbalance in oxygen supply/demand) were adjudicated according to the universal definition of MI. From the 4573 patients admitted for acute MI, 466 (10%) had a concurrent acute infection (median age 78 (66–85) y, 60% male), of whom 313 (67%) had a respiratory tract infection. Type 2 MI was identified in 72% of post-infectious MI. Compared with other MI, post-infectious MI had a worse in-hospital outcome (11 vs. 6% mortality, p < 0.01), mostly from cardiovascular causes. After adjusting for confounders, acute infections were no more associated with mortality (odds ratio 0.72; 95% confidence interval 0.43–1.20). In the group of post-infectious MI, Type 1 MI and respiratory tract infection were associated with a worse prognosis (respective odds ratio 2.44; 95% confidence interval: 1.12–5.29, and 2.89; 1.19–6.99). In this large MI survey, post-infectious MI was common, accounting for 10% of all MI, and doubled in-hospital mortality. Respiratory tract infection and Type 1 post-infectious MI were associated with a worse prognosis.
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spelling pubmed-66166572019-07-18 Post-Infectious Myocardial Infarction: New Insights for Improved Screening Putot, Alain Chague, Frédéric Manckoundia, Patrick Cottin, Yves Zeller, Marianne J Clin Med Article Acute infection is suspected of involvement in the onset of acute myocardial infarction (MI). We aimed to assess the incidence, pathogenesis and prognosis of post-infectious MI. All consecutive patients hospitalized for an acute MI in coronary care units were prospectively included. Post-infectious MI was defined by a concurrent diagnosis of acute infection at admission. Type 1 MI (acute plaque disruption) or Type 2 MI (imbalance in oxygen supply/demand) were adjudicated according to the universal definition of MI. From the 4573 patients admitted for acute MI, 466 (10%) had a concurrent acute infection (median age 78 (66–85) y, 60% male), of whom 313 (67%) had a respiratory tract infection. Type 2 MI was identified in 72% of post-infectious MI. Compared with other MI, post-infectious MI had a worse in-hospital outcome (11 vs. 6% mortality, p < 0.01), mostly from cardiovascular causes. After adjusting for confounders, acute infections were no more associated with mortality (odds ratio 0.72; 95% confidence interval 0.43–1.20). In the group of post-infectious MI, Type 1 MI and respiratory tract infection were associated with a worse prognosis (respective odds ratio 2.44; 95% confidence interval: 1.12–5.29, and 2.89; 1.19–6.99). In this large MI survey, post-infectious MI was common, accounting for 10% of all MI, and doubled in-hospital mortality. Respiratory tract infection and Type 1 post-infectious MI were associated with a worse prognosis. MDPI 2019-06-11 /pmc/articles/PMC6616657/ /pubmed/31212586 http://dx.doi.org/10.3390/jcm8060827 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Putot, Alain
Chague, Frédéric
Manckoundia, Patrick
Cottin, Yves
Zeller, Marianne
Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title_full Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title_fullStr Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title_full_unstemmed Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title_short Post-Infectious Myocardial Infarction: New Insights for Improved Screening
title_sort post-infectious myocardial infarction: new insights for improved screening
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616657/
https://www.ncbi.nlm.nih.gov/pubmed/31212586
http://dx.doi.org/10.3390/jcm8060827
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