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Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly

Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investiga...

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Autores principales: Wang, Tzu-Chueh, Ku, Pou-Jen, Lu, Hai-Lin, Hsu, Kung-Chuan, Trezise, Damien, Wang, Hue-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616857/
https://www.ncbi.nlm.nih.gov/pubmed/31226874
http://dx.doi.org/10.3390/ijerph16122189
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author Wang, Tzu-Chueh
Ku, Pou-Jen
Lu, Hai-Lin
Hsu, Kung-Chuan
Trezise, Damien
Wang, Hue-Yu
author_facet Wang, Tzu-Chueh
Ku, Pou-Jen
Lu, Hai-Lin
Hsu, Kung-Chuan
Trezise, Damien
Wang, Hue-Yu
author_sort Wang, Tzu-Chueh
collection PubMed
description Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investigate the continuous use of PIMs in a community-dwelling elderly population. A cross-sectional population-based study was conducted using community pharmacy–filed dispensing records from the Hcare system. Twenty-three community pharmacies were sampled from 2013 to 2015 to obtain records of patients above 65 years-old with continuous prescriptions. PIM were identified according to the 2015 Beers Criteria. The prevalence of patients using PIM was highest in patients with co-morbid mental disorders (40.05%), followed by neurological system disorders (28.91%). Patients who were prescribed a PIM were more than three times as likely to have a mental disorder as those (odds ratio 3.16, 95% confidence interval: 3.06–3.28) with non-chronic diseases. The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%). Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed. Drug safety concerns should be closely monitored in elderly patients with the abovementioned conditions.
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spelling pubmed-66168572019-07-18 Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly Wang, Tzu-Chueh Ku, Pou-Jen Lu, Hai-Lin Hsu, Kung-Chuan Trezise, Damien Wang, Hue-Yu Int J Environ Res Public Health Article Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investigate the continuous use of PIMs in a community-dwelling elderly population. A cross-sectional population-based study was conducted using community pharmacy–filed dispensing records from the Hcare system. Twenty-three community pharmacies were sampled from 2013 to 2015 to obtain records of patients above 65 years-old with continuous prescriptions. PIM were identified according to the 2015 Beers Criteria. The prevalence of patients using PIM was highest in patients with co-morbid mental disorders (40.05%), followed by neurological system disorders (28.91%). Patients who were prescribed a PIM were more than three times as likely to have a mental disorder as those (odds ratio 3.16, 95% confidence interval: 3.06–3.28) with non-chronic diseases. The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%). Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed. Drug safety concerns should be closely monitored in elderly patients with the abovementioned conditions. MDPI 2019-06-20 2019-06 /pmc/articles/PMC6616857/ /pubmed/31226874 http://dx.doi.org/10.3390/ijerph16122189 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Tzu-Chueh
Ku, Pou-Jen
Lu, Hai-Lin
Hsu, Kung-Chuan
Trezise, Damien
Wang, Hue-Yu
Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title_full Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title_fullStr Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title_full_unstemmed Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title_short Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly
title_sort association between potentially inappropriate medication use and chronic diseases in the elderly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616857/
https://www.ncbi.nlm.nih.gov/pubmed/31226874
http://dx.doi.org/10.3390/ijerph16122189
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