Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarboxylic acid (TCA) cycle underpin this switch to a pro-inflamm...

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Detalles Bibliográficos
Autores principales: Bailey, Jade D., Diotallevi, Marina, Nicol, Thomas, McNeill, Eileen, Shaw, Andrew, Chuaiphichai, Surawee, Hale, Ashley, Starr, Anna, Nandi, Manasi, Stylianou, Elena, McShane, Helen, Davis, Simon, Fischer, Roman, Kessler, Benedikt M., McCullagh, James, Channon, Keith M., Crabtree, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616861/
https://www.ncbi.nlm.nih.gov/pubmed/31269442
http://dx.doi.org/10.1016/j.celrep.2019.06.018

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