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Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford
(1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that aluminium played a role in the death of a Camelford resid...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616903/ https://www.ncbi.nlm.nih.gov/pubmed/31208130 http://dx.doi.org/10.3390/ijerph16122129 |
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author | Mold, Matthew Cottle, Jason Exley, Christopher |
author_facet | Mold, Matthew Cottle, Jason Exley, Christopher |
author_sort | Mold, Matthew |
collection | PubMed |
description | (1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that aluminium played a role in the death of a Camelford resident following development of late-onset epilepsy. (2) Case summary: We have measured the aluminium content of brain tissue in this individual and demonstrated significant accumulations of aluminium in the hippocampus (4.35 (2.80) µg/g dry wt.) and the occipital lobe (2.22 (2.23) µg/g dry wt., mean, SD, n = 5), the latter being associated with abnormal calcifications. Aluminium-specific fluorescence microscopy confirmed the presence of aluminium in both of these tissues and made the consistent observation of aluminium-loaded glial cells in close proximity to aluminium-rich cell/neuronal debris. These observations support an inflammatory component in this case of late-onset epilepsy. Congo red failed to identify any amyloid deposits in any tissue while thioflavin S showed extensive extracellular and intracellular tau pathologies. (3) Discussion: We present the first data showing aluminium in brain tissue in epilepsy and suggest, in light of complementary evidence from scientific literature, the first evidence that aluminium played a role in the advent of this case of late-onset adult epilepsy. |
format | Online Article Text |
id | pubmed-6616903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66169032019-07-18 Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford Mold, Matthew Cottle, Jason Exley, Christopher Int J Environ Res Public Health Case Report (1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that aluminium played a role in the death of a Camelford resident following development of late-onset epilepsy. (2) Case summary: We have measured the aluminium content of brain tissue in this individual and demonstrated significant accumulations of aluminium in the hippocampus (4.35 (2.80) µg/g dry wt.) and the occipital lobe (2.22 (2.23) µg/g dry wt., mean, SD, n = 5), the latter being associated with abnormal calcifications. Aluminium-specific fluorescence microscopy confirmed the presence of aluminium in both of these tissues and made the consistent observation of aluminium-loaded glial cells in close proximity to aluminium-rich cell/neuronal debris. These observations support an inflammatory component in this case of late-onset epilepsy. Congo red failed to identify any amyloid deposits in any tissue while thioflavin S showed extensive extracellular and intracellular tau pathologies. (3) Discussion: We present the first data showing aluminium in brain tissue in epilepsy and suggest, in light of complementary evidence from scientific literature, the first evidence that aluminium played a role in the advent of this case of late-onset adult epilepsy. MDPI 2019-06-16 2019-06 /pmc/articles/PMC6616903/ /pubmed/31208130 http://dx.doi.org/10.3390/ijerph16122129 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Mold, Matthew Cottle, Jason Exley, Christopher Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title | Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title_full | Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title_fullStr | Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title_full_unstemmed | Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title_short | Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford |
title_sort | aluminium in brain tissue in epilepsy: a case report from camelford |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616903/ https://www.ncbi.nlm.nih.gov/pubmed/31208130 http://dx.doi.org/10.3390/ijerph16122129 |
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