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Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence
Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616959/ https://www.ncbi.nlm.nih.gov/pubmed/31234300 http://dx.doi.org/10.3390/antiox8060188 |
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author | Vlavcheski, Filip Young, Mariah Tsiani, Evangelia |
author_facet | Vlavcheski, Filip Young, Mariah Tsiani, Evangelia |
author_sort | Vlavcheski, Filip |
collection | PubMed |
description | Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention strategies are considerably lacking in number and efficacy and therefore new targeted therapies and preventative strategies are urgently needed. Plant-derived chemicals such as metformin, derived from the French lilac, have been used to treat/manage insulin resistance and T2DM. Other plant-derived chemicals which are not yet discovered, may have superior properties to prevent and manage T2DM and thus research into this area is highly justifiable. Hydroxytyrosol is a phenolic phytochemical found in olive leaves and olive oil reported to have antioxidant, anti-inflammatory, anticancer and antidiabetic properties. The present review summarizes the current in vitro and in vivo studies examining the antidiabetic properties of hydroxytyrosol and investigating the mechanisms of its action. |
format | Online Article Text |
id | pubmed-6616959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66169592019-07-18 Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence Vlavcheski, Filip Young, Mariah Tsiani, Evangelia Antioxidants (Basel) Review Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention strategies are considerably lacking in number and efficacy and therefore new targeted therapies and preventative strategies are urgently needed. Plant-derived chemicals such as metformin, derived from the French lilac, have been used to treat/manage insulin resistance and T2DM. Other plant-derived chemicals which are not yet discovered, may have superior properties to prevent and manage T2DM and thus research into this area is highly justifiable. Hydroxytyrosol is a phenolic phytochemical found in olive leaves and olive oil reported to have antioxidant, anti-inflammatory, anticancer and antidiabetic properties. The present review summarizes the current in vitro and in vivo studies examining the antidiabetic properties of hydroxytyrosol and investigating the mechanisms of its action. MDPI 2019-06-21 /pmc/articles/PMC6616959/ /pubmed/31234300 http://dx.doi.org/10.3390/antiox8060188 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vlavcheski, Filip Young, Mariah Tsiani, Evangelia Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title | Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title_full | Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title_fullStr | Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title_full_unstemmed | Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title_short | Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence |
title_sort | antidiabetic effects of hydroxytyrosol: in vitro and in vivo evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616959/ https://www.ncbi.nlm.nih.gov/pubmed/31234300 http://dx.doi.org/10.3390/antiox8060188 |
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