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γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study

Although it has been suggested that the γ-glutamyltransferase (GGT) level is an indicator of cardiometabolic disorders, there is no previous study to evaluate the implication of GGT variability on the development of myocardial infarction (MI), stroke, all-cause mortality, and cardiovascular disease...

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Autores principales: Chung, Hye Soo, Lee, Ji Sung, Kim, Jung A., Roh, Eun, Lee, You Bin, Hong, So Hyeon, Yoo, Hye Jin, Baik, Sei Hyun, Kim, Nan Hee, Seo, Ji A, Kim, Sin Gon, Kim, Nam Hoon, Choi, Kyung Mook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617005/
https://www.ncbi.nlm.nih.gov/pubmed/31212805
http://dx.doi.org/10.3390/jcm8060832
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author Chung, Hye Soo
Lee, Ji Sung
Kim, Jung A.
Roh, Eun
Lee, You Bin
Hong, So Hyeon
Yoo, Hye Jin
Baik, Sei Hyun
Kim, Nan Hee
Seo, Ji A
Kim, Sin Gon
Kim, Nam Hoon
Choi, Kyung Mook
author_facet Chung, Hye Soo
Lee, Ji Sung
Kim, Jung A.
Roh, Eun
Lee, You Bin
Hong, So Hyeon
Yoo, Hye Jin
Baik, Sei Hyun
Kim, Nan Hee
Seo, Ji A
Kim, Sin Gon
Kim, Nam Hoon
Choi, Kyung Mook
author_sort Chung, Hye Soo
collection PubMed
description Although it has been suggested that the γ-glutamyltransferase (GGT) level is an indicator of cardiometabolic disorders, there is no previous study to evaluate the implication of GGT variability on the development of myocardial infarction (MI), stroke, all-cause mortality, and cardiovascular disease (CVD)-related mortality. GGT variability was measured as the coefficient variance (GGT-CV), standard deviation (GGT-SD), and variability independent of the mean (GGT-VIM). Using the population-based Korean National Health Insurance Service-Health Screening Cohort, we followed 158,736 Korean adults over a median duration of 8.4 years. In multivariable Cox proportional hazard analysis, the risk of mortality, MI, and stroke showed a stepwise increase according to the quartiles of GGT-CV, GGT-SD or GGT-VIM. In the highest quartile of GGT-CV compared to the lowest quartile after adjusting for confounding variables including mean GGT, the hazard ratios (HRs) for incident MI, stroke, mortality, and CVD-related mortality were 1.19 (95% confidence interval (CI), 1.06–1.34; p < 0.001), 1.20 (95% CI, 1.10–1.32; p < 0.001), 1.41 (95% CI, 1.33–1.51; p < 0.001), and 1.52 (95% CI, 1.30–1.78; p < 0.001), respectively, which were similar or even higher compared with those associated with total cholesterol variability. This is the first study to demonstrate that high GGT variability is associated with increased risk of MI, stroke, all-cause mortality, and CVD-related mortality in the general population.
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spelling pubmed-66170052019-07-18 γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study Chung, Hye Soo Lee, Ji Sung Kim, Jung A. Roh, Eun Lee, You Bin Hong, So Hyeon Yoo, Hye Jin Baik, Sei Hyun Kim, Nan Hee Seo, Ji A Kim, Sin Gon Kim, Nam Hoon Choi, Kyung Mook J Clin Med Article Although it has been suggested that the γ-glutamyltransferase (GGT) level is an indicator of cardiometabolic disorders, there is no previous study to evaluate the implication of GGT variability on the development of myocardial infarction (MI), stroke, all-cause mortality, and cardiovascular disease (CVD)-related mortality. GGT variability was measured as the coefficient variance (GGT-CV), standard deviation (GGT-SD), and variability independent of the mean (GGT-VIM). Using the population-based Korean National Health Insurance Service-Health Screening Cohort, we followed 158,736 Korean adults over a median duration of 8.4 years. In multivariable Cox proportional hazard analysis, the risk of mortality, MI, and stroke showed a stepwise increase according to the quartiles of GGT-CV, GGT-SD or GGT-VIM. In the highest quartile of GGT-CV compared to the lowest quartile after adjusting for confounding variables including mean GGT, the hazard ratios (HRs) for incident MI, stroke, mortality, and CVD-related mortality were 1.19 (95% confidence interval (CI), 1.06–1.34; p < 0.001), 1.20 (95% CI, 1.10–1.32; p < 0.001), 1.41 (95% CI, 1.33–1.51; p < 0.001), and 1.52 (95% CI, 1.30–1.78; p < 0.001), respectively, which were similar or even higher compared with those associated with total cholesterol variability. This is the first study to demonstrate that high GGT variability is associated with increased risk of MI, stroke, all-cause mortality, and CVD-related mortality in the general population. MDPI 2019-06-12 /pmc/articles/PMC6617005/ /pubmed/31212805 http://dx.doi.org/10.3390/jcm8060832 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chung, Hye Soo
Lee, Ji Sung
Kim, Jung A.
Roh, Eun
Lee, You Bin
Hong, So Hyeon
Yoo, Hye Jin
Baik, Sei Hyun
Kim, Nan Hee
Seo, Ji A
Kim, Sin Gon
Kim, Nam Hoon
Choi, Kyung Mook
γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title_full γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title_fullStr γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title_full_unstemmed γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title_short γ-Glutamyltransferase Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Cohort Study
title_sort γ-glutamyltransferase variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617005/
https://www.ncbi.nlm.nih.gov/pubmed/31212805
http://dx.doi.org/10.3390/jcm8060832
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