Cargando…

Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with a long half-life, high selectivity, and rapid onset of action. Because the safety of using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been a problem worldwide, this paper primarily focuses on the safety assess...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maki, Shintaro, Tanaka, Hiroaki, Tsuji, Makoto, Furuhashi, Fumi, Magawa, Shoichi, Kaneda, Michiko K., Nii, Masafumi, Tanaka, Kayo, Kondo, Eiji, Tamaru, Satoshi, Ogura, Toru, Nishimura, Yuki, Endoh, Masayuki, Kimura, Tadashi, Kotani, Tomomi, Sekizawa, Akihiko, Ikeda, Tomoaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617029/ https://www.ncbi.nlm.nih.gov/pubmed/31208060 http://dx.doi.org/10.3390/jcm8060856

Ejemplares similares

TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial
por: Umekawa, Takashi, et al.
Publicado: (2018)

Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb)
por: Maki, Shintaro, et al.
Publicado: (2022)

Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy
por: Tanaka, Hiroaki, et al.
Publicado: (2019)

Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions
por: Tachibana, Ryota, et al.
Publicado: (2019)

Fetal Biometric Assessment and Infant Developmental Prognosis of the Tadalafil Treatment for Fetal Growth Restriction
por: Tsuji, Makoto, et al.
Publicado: (2023)

Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction
por: Tsuchiya, Kyoka, et al.
Publicado: (2020)

Developmental Evaluation of Infants Who Have Received Tadalafil in Utero for Fetal Growth Restriction
por: Maki, Shintaro, et al.
Publicado: (2020)

Accurate evaluation of the progress of delivery with transperineal ultrasound may improve vaginal delivery: a single-center retrospective study
por: Enomoto, Naosuke, et al.
Publicado: (2023)

Appropriate Method of Administering Vasopressors for Maternal Hypotension Associated with Combined Spinal Epidural Anesthesia in Elective Cesarean Section: Impact on Postnatal Respiratory Support for Newborns
por: Magawa, Shoichi, et al.
Publicado: (2022)

Early-onset fetal growth restriction treated with the long-acting phosphodiesterase-5 inhibitor tadalafil: a case report
por: Sakamoto, Mito, et al.
Publicado: (2016)

Relationship between Edinburg Postnatal Depression Scale (EPDS) Scores in the Early Postpartum Period and Related Stress Coping Characteristics
por: Magawa, Shoichi, et al.
Publicado: (2022)

Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring
por: Kawamura, Takuya, et al.
Publicado: (2021)

Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling
por: Tanaka, Kayo, et al.
Publicado: (2022)

Evaluation of fetal acidemia during delivery using the conventional 5-tier classification and Rainbow systems
por: Magawa, Shoichi, et al.
Publicado: (2023)

Antenatal Indomethacin Treatment for Congenital Myotonic Dystrophy
por: Yamaguchi, Kyohei, et al.
Publicado: (2019)

Does Vaginal Cuff Creation and Avoidance of a Uterine Manipulator Improve the Prognosis of Total Laparoscopic Radical Hysterectomy for Early Cervical Cancer? A Retrospective Multicenter Study
por: Kondo, Eiji, et al.
Publicado: (2022)

Risk Factors for Cardiovascular Events among Pregnant Women with Cardiovascular Disease
por: Nii, Masafumi, et al.
Publicado: (2020)

Pretreatment with tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats
por: Nagashima, Yoshiyasu, et al.
Publicado: (2023)

Factors for the development of anemia in patients with newly introduced olaparib: A retrospective case-control study
por: Chihiro, Shiraishi, et al.
Publicado: (2023)

Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia
por: Tanaka, Tomoaki, et al.
Publicado: (2018)

Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
por: Tanaka, Hiroaki, et al.
Publicado: (2021)

Safety and Efficacy of Laparoscopic Oophorocystectomy for Ovarian Dermoid Cyst Associated With Autoimmune Hemolytic Anemia
por: Nii, Masafumi, et al.
Publicado: (2018)

Placental growth factor level is correlated with intrapartum fetal heart rate findings
por: Tanaka, Hiroaki, et al.
Publicado: (2022)

Tadalafil in the treatment of erectile dysfunction
por: Coward, Robert M, et al.
Publicado: (2008)

Myopathy with Concurrent Tadalafil and Simvastatin
por: Gargante, Maria Pia, et al.
Publicado: (2009)

Are There Maternal Deaths Related to Hemorrhagic Stroke Due to Hypertensive Disorder of Pregnancy That Could Be Potentially Preventable by Tight Hypertension Management in Antepartum? A Retrospective Study from the Maternal Death Exploratory Committee in Japan
por: Tanaka, Hiroaki, et al.
Publicado: (2023)

Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases
por: Brock, Gerald, et al.
Publicado: (2016)

High maternal mortality rate associated with advanced maternal age in Japan
por: Tanaka, Hiroaki, et al.
Publicado: (2023)

Central Serous Chorioretinopathy Associated with Tadalafil
por: Alsarhani, Abdulaziz, et al.
Publicado: (2022)

Cancer-associated gene analysis of cervical cytology samples and liquid-based cytology significantly improve endometrial cancer diagnosis sensitivity
por: Nimura, Ryo, et al.
Publicado: (2022)

MR Imaging of Fetuses to Evaluate Placental Insufficiency
por: OHGIYA, Yoshimitsu, et al.
Publicado: (2015)

Meta-Analysis of the Long-Term Efficacy and Tolerance of Tadalafil Daily Compared With Tadalafil On-Demand in Treating Men With Erectile Dysfunction
por: Zhou, Zhongbao, et al.
Publicado: (2019)

Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease and Sleep Apnea Syndrome
por: Watanabe, Yu, et al.
Publicado: (2022)

The Effect of Grapefruit Juice on the Pharmacokinetics of Tadalafil in Rats
por: Shen, Xiuwei, et al.
Publicado: (2020)

Effects of sildenafil and tadalafil on skin flap viability
por: Souza, Rafael A. C., et al.
Publicado: (2021)

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)
por: Hassel, Jessica C., et al.
Publicado: (2017)

Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction
por: Mohamed, Soad A., et al.
Publicado: (2023)

Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction
por: Jang, Se Won, et al.
Publicado: (2022)

A Retrospectively Diagnosed Case of IgG4-Related Tubulointerstitial Nephritis Showing Good Renal Outcome and Pathological Progress
por: Wu, Qiong, et al.
Publicado: (2013)

Myocardial tissue characterization and strain analysis in healthy pregnant women using cardiovascular magnetic resonance native T1 mapping and feature tracking technique
por: Nii, Masafumi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_68g3rhj5nks8v886nkopfbe6dm