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Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects

Despite the potential relationship with metabolic derangements, the association between dietary carbohydrate intake and renal function remains unknown. The present study investigated the impact of dietary carbohydrate intake on the development of incident chronic kidney disease (CKD) in a large-scal...

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Autores principales: Nam, Ki Heon, An, Seong Yeong, Joo, Young Su, Lee, Sangmi, Yun, Hae-Ryong, Jhee, Jong Hyun, Han, Seung Hyeok, Yoo, Tae-Hyun, Kang, Shin-Wook, Park, Jung Tak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617052/
https://www.ncbi.nlm.nih.gov/pubmed/31167515
http://dx.doi.org/10.3390/jcm8060793
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author Nam, Ki Heon
An, Seong Yeong
Joo, Young Su
Lee, Sangmi
Yun, Hae-Ryong
Jhee, Jong Hyun
Han, Seung Hyeok
Yoo, Tae-Hyun
Kang, Shin-Wook
Park, Jung Tak
author_facet Nam, Ki Heon
An, Seong Yeong
Joo, Young Su
Lee, Sangmi
Yun, Hae-Ryong
Jhee, Jong Hyun
Han, Seung Hyeok
Yoo, Tae-Hyun
Kang, Shin-Wook
Park, Jung Tak
author_sort Nam, Ki Heon
collection PubMed
description Despite the potential relationship with metabolic derangements, the association between dietary carbohydrate intake and renal function remains unknown. The present study investigated the impact of dietary carbohydrate intake on the development of incident chronic kidney disease (CKD) in a large-scale prospective cohort with normal renal function. A total of 6746 and 1058 subjects without and with diabetes mellitus (DM) were analyzed, respectively. Carbohydrate intake was assessed by a 24-h dietary recall food frequency questionnaire. The primary endpoint was CKD development, defined as a composite of estimated glomerular filtration rate (eGFR) of ≤60 mL/min/1.73 m(2) and the development of proteinuria. CKD newly developed in 20.1% and 36.0% of subjects during median follow-ups of 140 and 119 months in the non-DM and DM subjects, respectively. Categorization of non-DM subjects into dietary carbohydrate density quartiles revealed a significantly higher risk of CKD development in the third and fourth quartiles than in the first quartile (P = 0.037 for first vs. third; P = 0.001 for first vs. fourth). A significant risk elevation was also found with increased carbohydrate density when carbohydrate density was treated as a continuous variable (P = 0.008). However, there was no significant difference in the incident CKD risk among those with DM according to dietary carbohydrate density quartiles. Carbohydrate-rich diets may increase the risk of CKD development in non-DM subjects.
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spelling pubmed-66170522019-07-18 Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects Nam, Ki Heon An, Seong Yeong Joo, Young Su Lee, Sangmi Yun, Hae-Ryong Jhee, Jong Hyun Han, Seung Hyeok Yoo, Tae-Hyun Kang, Shin-Wook Park, Jung Tak J Clin Med Article Despite the potential relationship with metabolic derangements, the association between dietary carbohydrate intake and renal function remains unknown. The present study investigated the impact of dietary carbohydrate intake on the development of incident chronic kidney disease (CKD) in a large-scale prospective cohort with normal renal function. A total of 6746 and 1058 subjects without and with diabetes mellitus (DM) were analyzed, respectively. Carbohydrate intake was assessed by a 24-h dietary recall food frequency questionnaire. The primary endpoint was CKD development, defined as a composite of estimated glomerular filtration rate (eGFR) of ≤60 mL/min/1.73 m(2) and the development of proteinuria. CKD newly developed in 20.1% and 36.0% of subjects during median follow-ups of 140 and 119 months in the non-DM and DM subjects, respectively. Categorization of non-DM subjects into dietary carbohydrate density quartiles revealed a significantly higher risk of CKD development in the third and fourth quartiles than in the first quartile (P = 0.037 for first vs. third; P = 0.001 for first vs. fourth). A significant risk elevation was also found with increased carbohydrate density when carbohydrate density was treated as a continuous variable (P = 0.008). However, there was no significant difference in the incident CKD risk among those with DM according to dietary carbohydrate density quartiles. Carbohydrate-rich diets may increase the risk of CKD development in non-DM subjects. MDPI 2019-06-04 /pmc/articles/PMC6617052/ /pubmed/31167515 http://dx.doi.org/10.3390/jcm8060793 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nam, Ki Heon
An, Seong Yeong
Joo, Young Su
Lee, Sangmi
Yun, Hae-Ryong
Jhee, Jong Hyun
Han, Seung Hyeok
Yoo, Tae-Hyun
Kang, Shin-Wook
Park, Jung Tak
Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title_full Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title_fullStr Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title_full_unstemmed Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title_short Carbohydrate-Rich Diet Is Associated with Increased Risk of Incident Chronic Kidney Disease in Non-Diabetic Subjects
title_sort carbohydrate-rich diet is associated with increased risk of incident chronic kidney disease in non-diabetic subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617052/
https://www.ncbi.nlm.nih.gov/pubmed/31167515
http://dx.doi.org/10.3390/jcm8060793
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