Cargando…

Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis

Background: Non-alcoholic fatty liver disease (NAFLD) is a serious health problem, but the dose-response relationship between sugar-sweetened beverages (SSBs) and NAFLD remains uncertain. Methods: A systematic review and dose-response meta-analysis were conducted following the PRISMA (Preferred Repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hongwei, Wang, Jue, Li, Zheng, Lam, Christopher Wai Kei, Xiao, Ying, Wu, Qibiao, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617076/
https://www.ncbi.nlm.nih.gov/pubmed/31234281
http://dx.doi.org/10.3390/ijerph16122192
_version_ 1783433608237678592
author Chen, Hongwei
Wang, Jue
Li, Zheng
Lam, Christopher Wai Kei
Xiao, Ying
Wu, Qibiao
Zhang, Wei
author_facet Chen, Hongwei
Wang, Jue
Li, Zheng
Lam, Christopher Wai Kei
Xiao, Ying
Wu, Qibiao
Zhang, Wei
author_sort Chen, Hongwei
collection PubMed
description Background: Non-alcoholic fatty liver disease (NAFLD) is a serious health problem, but the dose-response relationship between sugar-sweetened beverages (SSBs) and NAFLD remains uncertain. Methods: A systematic review and dose-response meta-analysis were conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Review Manager 5.3 and Stata 14.0 were used to combine trials and analyze data. The dose-response meta-analysis was performed by non-linear trend regression. Results: Twelve studies recruiting a total of 35,705 participants were included. The results showed that the consumption of SSBs was associated with 1.39-fold increased odds of NAFLD (95% CI: 1.29–1.50, p < 0.00001). The risk of NAFLD rose with an increased consumption of SSBs, while the consumptions of low doses (<1 cup/week), middle doses (1–6 cups/week) and high doses (≥7 cups/week) of SSBs increased the relative risk of NAFLD by 14%, 26% and 53%, respectively (p = 0.01, p < 0.00001, p = 0.03, respectively). Conclusions: This study demonstrates that consumers of SSBs are at significantly increased risk of NAFLD, and the consumption of SSBs has a dose-dependent effect on the risk of NAFLD. The findings of this study strengthen the evidence base for healthy dietary patterns and are meaningful for the primary prevention of NAFLD.
format Online
Article
Text
id pubmed-6617076
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66170762019-07-18 Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis Chen, Hongwei Wang, Jue Li, Zheng Lam, Christopher Wai Kei Xiao, Ying Wu, Qibiao Zhang, Wei Int J Environ Res Public Health Article Background: Non-alcoholic fatty liver disease (NAFLD) is a serious health problem, but the dose-response relationship between sugar-sweetened beverages (SSBs) and NAFLD remains uncertain. Methods: A systematic review and dose-response meta-analysis were conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Review Manager 5.3 and Stata 14.0 were used to combine trials and analyze data. The dose-response meta-analysis was performed by non-linear trend regression. Results: Twelve studies recruiting a total of 35,705 participants were included. The results showed that the consumption of SSBs was associated with 1.39-fold increased odds of NAFLD (95% CI: 1.29–1.50, p < 0.00001). The risk of NAFLD rose with an increased consumption of SSBs, while the consumptions of low doses (<1 cup/week), middle doses (1–6 cups/week) and high doses (≥7 cups/week) of SSBs increased the relative risk of NAFLD by 14%, 26% and 53%, respectively (p = 0.01, p < 0.00001, p = 0.03, respectively). Conclusions: This study demonstrates that consumers of SSBs are at significantly increased risk of NAFLD, and the consumption of SSBs has a dose-dependent effect on the risk of NAFLD. The findings of this study strengthen the evidence base for healthy dietary patterns and are meaningful for the primary prevention of NAFLD. MDPI 2019-06-21 2019-06 /pmc/articles/PMC6617076/ /pubmed/31234281 http://dx.doi.org/10.3390/ijerph16122192 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Hongwei
Wang, Jue
Li, Zheng
Lam, Christopher Wai Kei
Xiao, Ying
Wu, Qibiao
Zhang, Wei
Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title_full Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title_fullStr Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title_full_unstemmed Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title_short Consumption of Sugar-Sweetened Beverages Has a Dose-Dependent Effect on the Risk of Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Dose-Response Meta-Analysis
title_sort consumption of sugar-sweetened beverages has a dose-dependent effect on the risk of non-alcoholic fatty liver disease: an updated systematic review and dose-response meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617076/
https://www.ncbi.nlm.nih.gov/pubmed/31234281
http://dx.doi.org/10.3390/ijerph16122192
work_keys_str_mv AT chenhongwei consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT wangjue consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT lizheng consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT lamchristopherwaikei consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT xiaoying consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT wuqibiao consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis
AT zhangwei consumptionofsugarsweetenedbeverageshasadosedependenteffectontheriskofnonalcoholicfattyliverdiseaseanupdatedsystematicreviewanddoseresponsemetaanalysis