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Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT

Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant mo...

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Autores principales: Hill, Marcus, Cunningham, Richard N., Hathout, Rania M., Johnston, Christopher, Hardy, John G., Migaud, Marie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617385/
https://www.ncbi.nlm.nih.gov/pubmed/31200522
http://dx.doi.org/10.3390/jfb10020026
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author Hill, Marcus
Cunningham, Richard N.
Hathout, Rania M.
Johnston, Christopher
Hardy, John G.
Migaud, Marie E.
author_facet Hill, Marcus
Cunningham, Richard N.
Hathout, Rania M.
Johnston, Christopher
Hardy, John G.
Migaud, Marie E.
author_sort Hill, Marcus
collection PubMed
description Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function.
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spelling pubmed-66173852019-07-18 Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT Hill, Marcus Cunningham, Richard N. Hathout, Rania M. Johnston, Christopher Hardy, John G. Migaud, Marie E. J Funct Biomater Communication Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (Pseudomonas aeruginosa) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function. MDPI 2019-06-13 /pmc/articles/PMC6617385/ /pubmed/31200522 http://dx.doi.org/10.3390/jfb10020026 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Hill, Marcus
Cunningham, Richard N.
Hathout, Rania M.
Johnston, Christopher
Hardy, John G.
Migaud, Marie E.
Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title_full Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title_fullStr Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title_full_unstemmed Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title_short Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
title_sort formulation of antimicrobial tobramycin loaded plga nanoparticles via complexation with aot
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617385/
https://www.ncbi.nlm.nih.gov/pubmed/31200522
http://dx.doi.org/10.3390/jfb10020026
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