RAC1(P29S) Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1(P29S) in melanoma development and reveal that RAC1(P29S) activates PAK, AKT, and a gene expression program initiated by the SRF/MRTF transcriptional pathway, w...

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Detalles Bibliográficos
Autores principales: Lionarons, Daniël A., Hancock, David C., Rana, Sareena, East, Philip, Moore, Christopher, Murillo, Miguel M., Carvalho, Joana, Spencer-Dene, Bradley, Herbert, Eleanor, Stamp, Gordon, Damry, Djamil, Calado, Dinis P., Rosewell, Ian, Fritsch, Ralph, Neubig, Richard R., Molina-Arcas, Miriam, Downward, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617390/
https://www.ncbi.nlm.nih.gov/pubmed/31257073
http://dx.doi.org/10.1016/j.ccell.2019.05.015

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