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Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects

Endothelial dysfunction (ED), often linked to hypertriglyceridemia, is an early step of atherosclerosis. We investigated, in a randomized cross-over study, whether high-fat meal (HFM)-induced ED might be reduced by fruit juice or champagne containing polyphenols. Flow-mediated dilatation (FMD) and b...

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Autores principales: Rouyer, Olivier, Auger, Cyril, Charles, Anne-Laure, Talha, Samy, Meyer, Alain, Piquard, Francois, Andres, Emmanuel, Schini-Kerth, Valerie, Geny, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617404/
https://www.ncbi.nlm.nih.gov/pubmed/31208093
http://dx.doi.org/10.3390/jcm8060859
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author Rouyer, Olivier
Auger, Cyril
Charles, Anne-Laure
Talha, Samy
Meyer, Alain
Piquard, Francois
Andres, Emmanuel
Schini-Kerth, Valerie
Geny, Bernard
author_facet Rouyer, Olivier
Auger, Cyril
Charles, Anne-Laure
Talha, Samy
Meyer, Alain
Piquard, Francois
Andres, Emmanuel
Schini-Kerth, Valerie
Geny, Bernard
author_sort Rouyer, Olivier
collection PubMed
description Endothelial dysfunction (ED), often linked to hypertriglyceridemia, is an early step of atherosclerosis. We investigated, in a randomized cross-over study, whether high-fat meal (HFM)-induced ED might be reduced by fruit juice or champagne containing polyphenols. Flow-mediated dilatation (FMD) and biological parameters (lipid profile, glycemia, inflammation, and oxidative stress markers) were determined before and two and three hours after the HFM in 17 healthy young subjects (24.6 ± 0.9 years) drinking water, juice, or champagne. Considering the entire group, despite significant hypertriglyceridemia (from 0.77 ± 0.07 to 1.41 ± 0.18 mmol/L, p < 0.001) and a decrease in Low Density Lipoprotein (LDL), the FMD was not impaired. However, the FMD decreased in 10 subjects (from 10.73 ± 0.95 to 8.13 ± 0.86 and 8.07 ± 1.16%; p < 0.05 and p < 0.01; 2 and 3 h, respectively, after the HFM), without concomitant change in concentration reactive protein or reactive oxygen species, but with an increase in glycemia. In the same subjects, the FMD did not decrease when drinking juice or champagne. In conclusion, HFM can impair the endothelial function in healthy young subjects. Fruit juice, rich in anthocyanins and procyanidins, or champagne, rich in simple phenolic acids, might reduce such alterations, but further studies are needed to determine the underlying mechanisms, likely involving polyphenols.
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spelling pubmed-66174042019-07-18 Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects Rouyer, Olivier Auger, Cyril Charles, Anne-Laure Talha, Samy Meyer, Alain Piquard, Francois Andres, Emmanuel Schini-Kerth, Valerie Geny, Bernard J Clin Med Article Endothelial dysfunction (ED), often linked to hypertriglyceridemia, is an early step of atherosclerosis. We investigated, in a randomized cross-over study, whether high-fat meal (HFM)-induced ED might be reduced by fruit juice or champagne containing polyphenols. Flow-mediated dilatation (FMD) and biological parameters (lipid profile, glycemia, inflammation, and oxidative stress markers) were determined before and two and three hours after the HFM in 17 healthy young subjects (24.6 ± 0.9 years) drinking water, juice, or champagne. Considering the entire group, despite significant hypertriglyceridemia (from 0.77 ± 0.07 to 1.41 ± 0.18 mmol/L, p < 0.001) and a decrease in Low Density Lipoprotein (LDL), the FMD was not impaired. However, the FMD decreased in 10 subjects (from 10.73 ± 0.95 to 8.13 ± 0.86 and 8.07 ± 1.16%; p < 0.05 and p < 0.01; 2 and 3 h, respectively, after the HFM), without concomitant change in concentration reactive protein or reactive oxygen species, but with an increase in glycemia. In the same subjects, the FMD did not decrease when drinking juice or champagne. In conclusion, HFM can impair the endothelial function in healthy young subjects. Fruit juice, rich in anthocyanins and procyanidins, or champagne, rich in simple phenolic acids, might reduce such alterations, but further studies are needed to determine the underlying mechanisms, likely involving polyphenols. MDPI 2019-06-15 /pmc/articles/PMC6617404/ /pubmed/31208093 http://dx.doi.org/10.3390/jcm8060859 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rouyer, Olivier
Auger, Cyril
Charles, Anne-Laure
Talha, Samy
Meyer, Alain
Piquard, Francois
Andres, Emmanuel
Schini-Kerth, Valerie
Geny, Bernard
Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title_full Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title_fullStr Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title_full_unstemmed Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title_short Effects of a High Fat Meal Associated with Water, Juice, or Champagne Consumption on Endothelial Function and Markers of Oxidative Stress and Inflammation in Young, Healthy Subjects
title_sort effects of a high fat meal associated with water, juice, or champagne consumption on endothelial function and markers of oxidative stress and inflammation in young, healthy subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617404/
https://www.ncbi.nlm.nih.gov/pubmed/31208093
http://dx.doi.org/10.3390/jcm8060859
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