Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor

Human cytomegalovirus (HCMV) can persistently infect humans, but how HCMV avoids humoral immunity is not clear. The neonatal Fc receptor (FcRn) controls IgG transport from the mother to the fetus and prolongs IgG half-life. Here we show that US11 inhibits the assembly of FcRn with β(2)m and retains...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoyang, Palaniyandi, Senthilkumar, Zhu, Iowis, Tang, Jin, Li, Weizhong, Wu, Xiaoling, Ochsner, Susan Park, Pauza, C. David, Cohen, Jeffrey I., Zhu, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617459/
https://www.ncbi.nlm.nih.gov/pubmed/31289263
http://dx.doi.org/10.1038/s41467-019-10865-y

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