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Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis

The system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of the most commonly diagnosed malignancies, is increased by it gradual development into metastasis, most frequently i...

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Autores principales: Yao, Jian‐feng, Li, Xiao‐jun, Yan, Li‐kun, He, Sai, Zheng, Jian‐bao, Wang, Xiao‐rong, Zhou, Pei‐hua, Zhang, Li, Wei, Guang‐bing, Sun, Xue‐jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617765/
https://www.ncbi.nlm.nih.gov/pubmed/30897285
http://dx.doi.org/10.1002/jbt.22316
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author Yao, Jian‐feng
Li, Xiao‐jun
Yan, Li‐kun
He, Sai
Zheng, Jian‐bao
Wang, Xiao‐rong
Zhou, Pei‐hua
Zhang, Li
Wei, Guang‐bing
Sun, Xue‐jun
author_facet Yao, Jian‐feng
Li, Xiao‐jun
Yan, Li‐kun
He, Sai
Zheng, Jian‐bao
Wang, Xiao‐rong
Zhou, Pei‐hua
Zhang, Li
Wei, Guang‐bing
Sun, Xue‐jun
author_sort Yao, Jian‐feng
collection PubMed
description The system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of the most commonly diagnosed malignancies, is increased by it gradual development into metastasis, most frequently in the liver. Overexpression of c‐Met, the protein tyrosine kinase receptor for the HCF/scatter factor, has been implicated in the progression and metastasis of human colorectal carcinoma. In this study, we aimed to investigate the role of c‐Met in CRC liver metastasis and illustrate the clinical impact of regulating HGF/c‐Met signaling in patients with CRC liver metastasis. We found that (I) higher levels of c‐Met expression (mRNA and Protein) in CRC liver metastasis than primary CRC by assessing the patient tissue samples; (II) a positive correlation of c‐Met expression with tumor stages of CRC liver metastasis, as well as c‐Met expression in CRC, live metastasis concurred with regional lymph node metastasis; (III) the clinical impact of downregulation of HGF/c‐Met signaling on the reduction of proliferation and invasion in CRC liver metastasis. Therefore, we demonstrate that the regulation of HGF/c‐Met pathways may be a promising strategy in the treatment of patients with CRC liver metastasis.
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spelling pubmed-66177652019-07-22 Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis Yao, Jian‐feng Li, Xiao‐jun Yan, Li‐kun He, Sai Zheng, Jian‐bao Wang, Xiao‐rong Zhou, Pei‐hua Zhang, Li Wei, Guang‐bing Sun, Xue‐jun J Biochem Mol Toxicol Research Articles The system of hepatocyte growth factor (HGF) and its receptor c‐Met plays a critical role in tumor invasive growth and metastasis. The mortality rate of colorectal cancer (CRC), one of the most commonly diagnosed malignancies, is increased by it gradual development into metastasis, most frequently in the liver. Overexpression of c‐Met, the protein tyrosine kinase receptor for the HCF/scatter factor, has been implicated in the progression and metastasis of human colorectal carcinoma. In this study, we aimed to investigate the role of c‐Met in CRC liver metastasis and illustrate the clinical impact of regulating HGF/c‐Met signaling in patients with CRC liver metastasis. We found that (I) higher levels of c‐Met expression (mRNA and Protein) in CRC liver metastasis than primary CRC by assessing the patient tissue samples; (II) a positive correlation of c‐Met expression with tumor stages of CRC liver metastasis, as well as c‐Met expression in CRC, live metastasis concurred with regional lymph node metastasis; (III) the clinical impact of downregulation of HGF/c‐Met signaling on the reduction of proliferation and invasion in CRC liver metastasis. Therefore, we demonstrate that the regulation of HGF/c‐Met pathways may be a promising strategy in the treatment of patients with CRC liver metastasis. John Wiley and Sons Inc. 2019-03-21 2019-06 /pmc/articles/PMC6617765/ /pubmed/30897285 http://dx.doi.org/10.1002/jbt.22316 Text en © 2019 The Authors. Journal of Biochemical and Molecular Toxicology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Yao, Jian‐feng
Li, Xiao‐jun
Yan, Li‐kun
He, Sai
Zheng, Jian‐bao
Wang, Xiao‐rong
Zhou, Pei‐hua
Zhang, Li
Wei, Guang‐bing
Sun, Xue‐jun
Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title_full Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title_fullStr Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title_full_unstemmed Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title_short Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis
title_sort role of hgf/c‐met in the treatment of colorectal cancer with liver metastasis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617765/
https://www.ncbi.nlm.nih.gov/pubmed/30897285
http://dx.doi.org/10.1002/jbt.22316
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