The multiple flavors of GoU pairs in RNA

Wobble GU pairs (or GoU) occur frequently within double‐stranded RNA helices interspersed within the standard G═C and A─U Watson‐Crick pairs. However, other types of GoU pairs interacting on their Watson‐Crick edges have been observed. The structural and functional roles of such alternative GoU pair...

Descripción completa

Detalles Bibliográficos
Autores principales: Westhof, Eric, Yusupov, Marat, Yusupova, Gulnara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617799/
https://www.ncbi.nlm.nih.gov/pubmed/31033092
http://dx.doi.org/10.1002/jmr.2782
_version_ 1783433773117865984
author Westhof, Eric
Yusupov, Marat
Yusupova, Gulnara
author_facet Westhof, Eric
Yusupov, Marat
Yusupova, Gulnara
author_sort Westhof, Eric
collection PubMed
description Wobble GU pairs (or GoU) occur frequently within double‐stranded RNA helices interspersed within the standard G═C and A─U Watson‐Crick pairs. However, other types of GoU pairs interacting on their Watson‐Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation.
format Online
Article
Text
id pubmed-6617799
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-66177992019-07-22 The multiple flavors of GoU pairs in RNA Westhof, Eric Yusupov, Marat Yusupova, Gulnara J Mol Recognit Review Wobble GU pairs (or GoU) occur frequently within double‐stranded RNA helices interspersed within the standard G═C and A─U Watson‐Crick pairs. However, other types of GoU pairs interacting on their Watson‐Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation. John Wiley and Sons Inc. 2019-04-29 2019-08 /pmc/articles/PMC6617799/ /pubmed/31033092 http://dx.doi.org/10.1002/jmr.2782 Text en © 2019 The Authors Journal of Molecular Recognition Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Westhof, Eric
Yusupov, Marat
Yusupova, Gulnara
The multiple flavors of GoU pairs in RNA
title The multiple flavors of GoU pairs in RNA
title_full The multiple flavors of GoU pairs in RNA
title_fullStr The multiple flavors of GoU pairs in RNA
title_full_unstemmed The multiple flavors of GoU pairs in RNA
title_short The multiple flavors of GoU pairs in RNA
title_sort multiple flavors of gou pairs in rna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617799/
https://www.ncbi.nlm.nih.gov/pubmed/31033092
http://dx.doi.org/10.1002/jmr.2782
work_keys_str_mv AT westhoferic themultipleflavorsofgoupairsinrna
AT yusupovmarat themultipleflavorsofgoupairsinrna
AT yusupovagulnara themultipleflavorsofgoupairsinrna
AT westhoferic multipleflavorsofgoupairsinrna
AT yusupovmarat multipleflavorsofgoupairsinrna
AT yusupovagulnara multipleflavorsofgoupairsinrna

Ejemplares similares