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Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer
AIM: This study aimed to assess adequate conditions for omitting parametrectomy for stage IB1–IIA2 cervical cancer with the aim of reducing postoperative complications during Type III radical hysterectomy (RH). METHODS: We investigated factors associated with parametrial invasion (PMI) in patients w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617803/ https://www.ncbi.nlm.nih.gov/pubmed/31106933 http://dx.doi.org/10.1111/jog.13986 |
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author | Ito, Fuminori Sugiura, Atsushi Toyoda, Shinji Itani, Yoshio Iwai, Kana Yamada, Yuki Tanase, Yasuhito Kawaguchi, Ryuji Kobayashi, Hiroshi Kita, Tsunekazu |
author_facet | Ito, Fuminori Sugiura, Atsushi Toyoda, Shinji Itani, Yoshio Iwai, Kana Yamada, Yuki Tanase, Yasuhito Kawaguchi, Ryuji Kobayashi, Hiroshi Kita, Tsunekazu |
author_sort | Ito, Fuminori |
collection | PubMed |
description | AIM: This study aimed to assess adequate conditions for omitting parametrectomy for stage IB1–IIA2 cervical cancer with the aim of reducing postoperative complications during Type III radical hysterectomy (RH). METHODS: We investigated factors associated with parametrial invasion (PMI) in patients who underwent Type III RH for stage IB1, IB2, IIA1, IIA2 and IIB cervical cancer at two tertiary institutions from November 2006 to February 2018. Both clinicopathological and preoperatively estimated factors were assessed. RESULTS: One hundred fifty‐six patients were preoperatively diagnosed with stage IB1 to IIB disease. Thirty‐four patients (21.8%) showed PMI on histological analyses. In the multivariate analysis, an age older than 50 years, tumor size larger than 40 mm, common iliac lymph node metastasis and lymphovascular space invasion were identified as significant risk factors for PMI (P‐values = 0.008, 0.003, 0.004 and 0.004, respectively). The preoperatively estimated risk factors for PMI were an older age, larger tumor size, and common iliac lymph node metastasis (P‐values = 0.007, 0.002 and 0.001, respectively). A combination of these three factors was sufficient to estimate PMI with a high specificity (100%) and positive predictive value (100%) in patients with stage IB1 to IIA2 disease. CONCLUSION: During RH, resecting the posterior layer of the vesicouterine ligament and the paracolpium without removing the cardinal ligament (avoiding parametrectomy) might be feasible for stage IB1–IIA2 cervical cancer in patients younger than 50 years presenting with smaller tumors (<40 mm) and no common iliac lymph node metastasis. |
format | Online Article Text |
id | pubmed-6617803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-66178032019-07-22 Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer Ito, Fuminori Sugiura, Atsushi Toyoda, Shinji Itani, Yoshio Iwai, Kana Yamada, Yuki Tanase, Yasuhito Kawaguchi, Ryuji Kobayashi, Hiroshi Kita, Tsunekazu J Obstet Gynaecol Res Original Articles AIM: This study aimed to assess adequate conditions for omitting parametrectomy for stage IB1–IIA2 cervical cancer with the aim of reducing postoperative complications during Type III radical hysterectomy (RH). METHODS: We investigated factors associated with parametrial invasion (PMI) in patients who underwent Type III RH for stage IB1, IB2, IIA1, IIA2 and IIB cervical cancer at two tertiary institutions from November 2006 to February 2018. Both clinicopathological and preoperatively estimated factors were assessed. RESULTS: One hundred fifty‐six patients were preoperatively diagnosed with stage IB1 to IIB disease. Thirty‐four patients (21.8%) showed PMI on histological analyses. In the multivariate analysis, an age older than 50 years, tumor size larger than 40 mm, common iliac lymph node metastasis and lymphovascular space invasion were identified as significant risk factors for PMI (P‐values = 0.008, 0.003, 0.004 and 0.004, respectively). The preoperatively estimated risk factors for PMI were an older age, larger tumor size, and common iliac lymph node metastasis (P‐values = 0.007, 0.002 and 0.001, respectively). A combination of these three factors was sufficient to estimate PMI with a high specificity (100%) and positive predictive value (100%) in patients with stage IB1 to IIA2 disease. CONCLUSION: During RH, resecting the posterior layer of the vesicouterine ligament and the paracolpium without removing the cardinal ligament (avoiding parametrectomy) might be feasible for stage IB1–IIA2 cervical cancer in patients younger than 50 years presenting with smaller tumors (<40 mm) and no common iliac lymph node metastasis. John Wiley & Sons Australia, Ltd 2019-05-20 2019-07 /pmc/articles/PMC6617803/ /pubmed/31106933 http://dx.doi.org/10.1111/jog.13986 Text en © 2019 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Ito, Fuminori Sugiura, Atsushi Toyoda, Shinji Itani, Yoshio Iwai, Kana Yamada, Yuki Tanase, Yasuhito Kawaguchi, Ryuji Kobayashi, Hiroshi Kita, Tsunekazu Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title | Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title_full | Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title_fullStr | Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title_full_unstemmed | Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title_short | Search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
title_sort | search for conditions to avoid parametrectomy during radical hysterectomy for cervical cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617803/ https://www.ncbi.nlm.nih.gov/pubmed/31106933 http://dx.doi.org/10.1111/jog.13986 |
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