Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid

All‐trans‐retinoic acid (at RA) downregulates cytochrome P450 (CYP)2D6 in several model systems. The aim of this study was to determine whether all active retinoids downregulate CYP2D6 and whether in vitro downregulation translates to in vivo drug–drug interactions (DDIs). The retinoids at RA, 13cis...

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Detalles Bibliográficos
Autores principales: Stevison, Faith, Kosaka, Mika, Kenny, Jane R., Wong, Susan, Hogarth, Cathryn, Amory, John K., Isoherranen, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617839/
https://www.ncbi.nlm.nih.gov/pubmed/30681285
http://dx.doi.org/10.1111/cts.12616

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