Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells

BACKGROUND: The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β produced by tumor cells promotes tolerance via expansion of Tregs. Our gro...

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Detalles Bibliográficos
Autores principales: Polanczyk, Magdalena J., Walker, Edwin, Haley, Daniel, Guerrouahen, Bella S., Akporiaye, Emmanuel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617864/
https://www.ncbi.nlm.nih.gov/pubmed/31288845
http://dx.doi.org/10.1186/s12967-019-1967-3

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