Cargando…

Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function

Radiofrequency (RF) treatment is an invasive and promising procedure in the treatment of osteoarthritis (OA). A meta-analysis based on 12 RCT studies was to investigate whether invasive RF treatment is more effective in relieving knee pain and improving knee function. Relevant studies were searched...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Tao, Wang, Haiyuan, Li, Guangxiao, Yao, Peng, Ding, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617930/
https://www.ncbi.nlm.nih.gov/pubmed/31346525
http://dx.doi.org/10.1155/2019/9037510
_version_ 1783433804775424000
author Hong, Tao
Wang, Haiyuan
Li, Guangxiao
Yao, Peng
Ding, Yuanyuan
author_facet Hong, Tao
Wang, Haiyuan
Li, Guangxiao
Yao, Peng
Ding, Yuanyuan
author_sort Hong, Tao
collection PubMed
description Radiofrequency (RF) treatment is an invasive and promising procedure in the treatment of osteoarthritis (OA). A meta-analysis based on 12 RCT studies was to investigate whether invasive RF treatment is more effective in relieving knee pain and improving knee function. Relevant studies were searched on database of Pubmed, Embase, EBSCO, Cochrane library, Wanfang digital database, VIP database, and CNKI up to January 2018. A total of 841 participants from 12 publications were included. The weighted mean difference (WMD) and the corresponding 95% CIs were used to evaluate the difference in pain scores and OKS/WOMAC scores between RF treatment and control groups. The statistical analysis was performed by Stata 12.0. The pain scores (VAS) in the RF group were lower than those in the conservative treatment group after 1 week (WMD -1.77, 95% CI -2.93 to -0.61, P<0.01), 1 month (WMD -1.40, 95% CI -1.98 to -0.82, P<0.01), and 3 months (WMD -1.32, 95% CI -2.27 to -0.37, P<0.01) of treatment, while there was no significant improvement in knee function. In subgroup analyses by site of radiofrequency, RF mode showed some discrepancies in the WMD of VAS between the treatment and control groups. In addition, subgroup analysis and meta-regression showed that the efficacy of RF treatment for reducing pain is reversely related to female ratio, and we did not find any surgery-related adverse reactions. RF treatment significantly reduces the knee pain, but rarely improves the knee joint function. Radiofrequency ablation has better efficacy than pulsed radiofrequency ablation in reducing pain. Furthermore, subgroup analysis and meta-regression suggested that women are more sensitive to RF treatment than men.
format Online
Article
Text
id pubmed-6617930
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66179302019-07-25 Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function Hong, Tao Wang, Haiyuan Li, Guangxiao Yao, Peng Ding, Yuanyuan Biomed Res Int Review Article Radiofrequency (RF) treatment is an invasive and promising procedure in the treatment of osteoarthritis (OA). A meta-analysis based on 12 RCT studies was to investigate whether invasive RF treatment is more effective in relieving knee pain and improving knee function. Relevant studies were searched on database of Pubmed, Embase, EBSCO, Cochrane library, Wanfang digital database, VIP database, and CNKI up to January 2018. A total of 841 participants from 12 publications were included. The weighted mean difference (WMD) and the corresponding 95% CIs were used to evaluate the difference in pain scores and OKS/WOMAC scores between RF treatment and control groups. The statistical analysis was performed by Stata 12.0. The pain scores (VAS) in the RF group were lower than those in the conservative treatment group after 1 week (WMD -1.77, 95% CI -2.93 to -0.61, P<0.01), 1 month (WMD -1.40, 95% CI -1.98 to -0.82, P<0.01), and 3 months (WMD -1.32, 95% CI -2.27 to -0.37, P<0.01) of treatment, while there was no significant improvement in knee function. In subgroup analyses by site of radiofrequency, RF mode showed some discrepancies in the WMD of VAS between the treatment and control groups. In addition, subgroup analysis and meta-regression showed that the efficacy of RF treatment for reducing pain is reversely related to female ratio, and we did not find any surgery-related adverse reactions. RF treatment significantly reduces the knee pain, but rarely improves the knee joint function. Radiofrequency ablation has better efficacy than pulsed radiofrequency ablation in reducing pain. Furthermore, subgroup analysis and meta-regression suggested that women are more sensitive to RF treatment than men. Hindawi 2019-06-26 /pmc/articles/PMC6617930/ /pubmed/31346525 http://dx.doi.org/10.1155/2019/9037510 Text en Copyright © 2019 Tao Hong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hong, Tao
Wang, Haiyuan
Li, Guangxiao
Yao, Peng
Ding, Yuanyuan
Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title_full Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title_fullStr Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title_full_unstemmed Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title_short Systematic Review and Meta-Analysis of 12 Randomized Controlled Trials Evaluating the Efficacy of Invasive Radiofrequency Treatment for Knee Pain and Function
title_sort systematic review and meta-analysis of 12 randomized controlled trials evaluating the efficacy of invasive radiofrequency treatment for knee pain and function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617930/
https://www.ncbi.nlm.nih.gov/pubmed/31346525
http://dx.doi.org/10.1155/2019/9037510
work_keys_str_mv AT hongtao systematicreviewandmetaanalysisof12randomizedcontrolledtrialsevaluatingtheefficacyofinvasiveradiofrequencytreatmentforkneepainandfunction
AT wanghaiyuan systematicreviewandmetaanalysisof12randomizedcontrolledtrialsevaluatingtheefficacyofinvasiveradiofrequencytreatmentforkneepainandfunction
AT liguangxiao systematicreviewandmetaanalysisof12randomizedcontrolledtrialsevaluatingtheefficacyofinvasiveradiofrequencytreatmentforkneepainandfunction
AT yaopeng systematicreviewandmetaanalysisof12randomizedcontrolledtrialsevaluatingtheefficacyofinvasiveradiofrequencytreatmentforkneepainandfunction
AT dingyuanyuan systematicreviewandmetaanalysisof12randomizedcontrolledtrialsevaluatingtheefficacyofinvasiveradiofrequencytreatmentforkneepainandfunction