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The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

OBJECTIVE: To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. MATERIALS AND METHODS: Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal templa...

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Autores principales: Swaan, Abel, Mannaerts, Christophe K., Muller, Berrend G., van Kollenburg, Rob AA., Lucas, Marit, Savci‐Heijink, C Dilara, van Leeuwen, Ton G., de Reijke, Theo M., de Bruin, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617991/
https://www.ncbi.nlm.nih.gov/pubmed/31090088
http://dx.doi.org/10.1002/lsm.23093
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author Swaan, Abel
Mannaerts, Christophe K.
Muller, Berrend G.
van Kollenburg, Rob AA.
Lucas, Marit
Savci‐Heijink, C Dilara
van Leeuwen, Ton G.
de Reijke, Theo M.
de Bruin, Daniel M.
author_facet Swaan, Abel
Mannaerts, Christophe K.
Muller, Berrend G.
van Kollenburg, Rob AA.
Lucas, Marit
Savci‐Heijink, C Dilara
van Leeuwen, Ton G.
de Reijke, Theo M.
de Bruin, Daniel M.
author_sort Swaan, Abel
collection PubMed
description OBJECTIVE: To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. MATERIALS AND METHODS: Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology. Three experts assessed all the corresponding OCT images. The OCT and biopsy conclusions for the corresponding regions were compared. RESULTS: No adverse events during and following the, in total four, in vivo needle‐based OCT measurements were reported. The OCT measurements showed images of prostatic tissue with a penetration depth of ~1.5 mm. The histological‐proven tissue types, which were also found in the overlapping OCT images, were benign glands, stroma, glandular atrophy, and adenocarcinoma (Gleason pattern 3). CONCLUSIONS: Clinical in vivo needle‐based OCT of the prostate is feasible with no adverse events during measurements. OCT images displayed detailed prostatic tissue with a imaging depth up to ~1.5 mm. We could co‐register four histological‐proven tissue types with OCT images. The feasibility of in vivo OCT in the prostate opens the pathway to the next phase of needle‐based OCT studies in the prostate. Lasers Surg. Med. 51:390–398, 2019. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.
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spelling pubmed-66179912019-07-22 The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study Swaan, Abel Mannaerts, Christophe K. Muller, Berrend G. van Kollenburg, Rob AA. Lucas, Marit Savci‐Heijink, C Dilara van Leeuwen, Ton G. de Reijke, Theo M. de Bruin, Daniel M. Lasers Surg Med Optical Coherence Tomography OBJECTIVE: To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. MATERIALS AND METHODS: Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology. Three experts assessed all the corresponding OCT images. The OCT and biopsy conclusions for the corresponding regions were compared. RESULTS: No adverse events during and following the, in total four, in vivo needle‐based OCT measurements were reported. The OCT measurements showed images of prostatic tissue with a penetration depth of ~1.5 mm. The histological‐proven tissue types, which were also found in the overlapping OCT images, were benign glands, stroma, glandular atrophy, and adenocarcinoma (Gleason pattern 3). CONCLUSIONS: Clinical in vivo needle‐based OCT of the prostate is feasible with no adverse events during measurements. OCT images displayed detailed prostatic tissue with a imaging depth up to ~1.5 mm. We could co‐register four histological‐proven tissue types with OCT images. The feasibility of in vivo OCT in the prostate opens the pathway to the next phase of needle‐based OCT studies in the prostate. Lasers Surg. Med. 51:390–398, 2019. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2019-05-14 2019-07 /pmc/articles/PMC6617991/ /pubmed/31090088 http://dx.doi.org/10.1002/lsm.23093 Text en © 2019 The Authors Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Optical Coherence Tomography
Swaan, Abel
Mannaerts, Christophe K.
Muller, Berrend G.
van Kollenburg, Rob AA.
Lucas, Marit
Savci‐Heijink, C Dilara
van Leeuwen, Ton G.
de Reijke, Theo M.
de Bruin, Daniel M.
The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title_full The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title_fullStr The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title_full_unstemmed The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title_short The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study
title_sort first in vivo needle‐based optical coherence tomography in human prostate: a safety and feasibility study
topic Optical Coherence Tomography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617991/
https://www.ncbi.nlm.nih.gov/pubmed/31090088
http://dx.doi.org/10.1002/lsm.23093
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