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Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size

Overlapping runs of homozygosity (ROH islands) shared by the majority of a population are hypothesized to be the result of selection around a target locus. In this study we investigated the impact of selection for coat color within the Noriker horse on autozygosity and ROH patterns. We analyzed over...

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Autores principales: Grilz‐Seger, G., Druml, T., Neuditschko, M., Mesarič, M., Cotman, M., Brem, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617995/
https://www.ncbi.nlm.nih.gov/pubmed/31199540
http://dx.doi.org/10.1111/age.12797
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author Grilz‐Seger, G.
Druml, T.
Neuditschko, M.
Mesarič, M.
Cotman, M.
Brem, G.
author_facet Grilz‐Seger, G.
Druml, T.
Neuditschko, M.
Mesarič, M.
Cotman, M.
Brem, G.
author_sort Grilz‐Seger, G.
collection PubMed
description Overlapping runs of homozygosity (ROH islands) shared by the majority of a population are hypothesized to be the result of selection around a target locus. In this study we investigated the impact of selection for coat color within the Noriker horse on autozygosity and ROH patterns. We analyzed overlapping homozygous regions (ROH islands) for gene content in fragments shared by more than 50% of horses. Long‐term assortative mating of chestnut horses and the small effective population size of leopard spotted and tobiano horses resulted in higher mean genome‐wide ROH coverage (S (ROH)) within the range of 237.4–284.2 Mb, whereas for bay, black and roan horses, where rotation mating is commonly applied, lower autozygosity (S (ROH) from 176.4–180.0 Mb) was determined. We identified seven common ROH islands considering all Noriker horses from our dataset. Specific islands were documented for chestnut, leopard spotted, roan and bay horses. The ROH islands contained, among others, genes associated with body size (ZFAT, LASP1 and LCORL/NCAPG), coat color (MC1R in chestnut and the factor PATN1 in leopard spotted horses) and morphogenesis (HOXB cluster in all color strains except leopard spotted horses). This study demonstrates that within a closed population sharing the same founders and ancestors, selection on a single phenotypic trait, in this case coat color, can result in genetic fragmentation affecting levels of autozygosity and distribution of ROH islands and enclosed gene content.
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spelling pubmed-66179952019-07-22 Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size Grilz‐Seger, G. Druml, T. Neuditschko, M. Mesarič, M. Cotman, M. Brem, G. Anim Genet Articles Overlapping runs of homozygosity (ROH islands) shared by the majority of a population are hypothesized to be the result of selection around a target locus. In this study we investigated the impact of selection for coat color within the Noriker horse on autozygosity and ROH patterns. We analyzed overlapping homozygous regions (ROH islands) for gene content in fragments shared by more than 50% of horses. Long‐term assortative mating of chestnut horses and the small effective population size of leopard spotted and tobiano horses resulted in higher mean genome‐wide ROH coverage (S (ROH)) within the range of 237.4–284.2 Mb, whereas for bay, black and roan horses, where rotation mating is commonly applied, lower autozygosity (S (ROH) from 176.4–180.0 Mb) was determined. We identified seven common ROH islands considering all Noriker horses from our dataset. Specific islands were documented for chestnut, leopard spotted, roan and bay horses. The ROH islands contained, among others, genes associated with body size (ZFAT, LASP1 and LCORL/NCAPG), coat color (MC1R in chestnut and the factor PATN1 in leopard spotted horses) and morphogenesis (HOXB cluster in all color strains except leopard spotted horses). This study demonstrates that within a closed population sharing the same founders and ancestors, selection on a single phenotypic trait, in this case coat color, can result in genetic fragmentation affecting levels of autozygosity and distribution of ROH islands and enclosed gene content. John Wiley and Sons Inc. 2019-06-14 2019-08 /pmc/articles/PMC6617995/ /pubmed/31199540 http://dx.doi.org/10.1111/age.12797 Text en © 2019 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Grilz‐Seger, G.
Druml, T.
Neuditschko, M.
Mesarič, M.
Cotman, M.
Brem, G.
Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title_full Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title_fullStr Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title_full_unstemmed Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title_short Analysis of ROH patterns in the Noriker horse breed reveals signatures of selection for coat color and body size
title_sort analysis of roh patterns in the noriker horse breed reveals signatures of selection for coat color and body size
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617995/
https://www.ncbi.nlm.nih.gov/pubmed/31199540
http://dx.doi.org/10.1111/age.12797
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