Cargando…

Highly‐expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β‐catenin and mTOR/HIF1α/VEGF signaling

The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth, invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast proliferation and osteodeposition and that high P2X7 expression has a pro‐growth effect in osteosarcoma. However, how it functions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yingchi, Cheng, Hao, Li, Wenkai, Wu, Hua, Yang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Molecular Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618011/ https://www.ncbi.nlm.nih.gov/pubmed/30761524 http://dx.doi.org/10.1002/ijc.32207

Ejemplares similares

Effects of osteoblast-derived extracellular vesicles on aggressiveness, redox status and mitochondrial bioenergetics of MNNG/HOS osteosarcoma cells
por: Ponzetti, Marco, et al.
Publicado: (2022)

Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathway
por: Xiang, Zijin, et al.
Publicado: (2020)

GSK3β Controls mTOR and Prosurvival Signaling in Neurons
por: Urbanska, Malgorzata, et al.
Publicado: (2017)

LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways
por: Liu, Zhihui, et al.
Publicado: (2020)

Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β‐catenin signaling pathway in breast cancer
por: Li, Kai, et al.
Publicado: (2018)

Cantharidin Inhibits Anti-Apoptotic Bcl-2 Family Proteins and Induces Apoptosis in Human Osteosarcoma Cell Lines MG-63 and MNNG/HOS via Mitochondria-Dependent Pathway
por: Feng, Shoumin, et al.
Publicado: (2018)

Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations
por: Park, Ye‐Lim, et al.
Publicado: (2018)

Electromagnetic field treatment increases purinergic receptor P2X7 expression and activates its downstream Akt/GSK3β/β-catenin axis in mesenchymal stem cells under osteogenic induction
por: Zhang, Yingchi, et al.
Publicado: (2019)

miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway
por: Zhou, Chun, et al.
Publicado: (2017)

GSK3β Is Involved in JNK2-Mediated β-Catenin Inhibition
por: Hu, Dong, et al.
Publicado: (2009)

Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway
por: Zhu, Feiye, et al.
Publicado: (2021)

Wnt-GSK3β/β-Catenin Regulates the Differentiation of Dental Pulp Stem Cells into Bladder Smooth Muscle Cells
por: Jiang, Wenkai, et al.
Publicado: (2019)

Cordycepin Regulates GSK-3β/β-Catenin Signaling in Human Leukemia Cells
por: Ko, Bor-Sheng, et al.
Publicado: (2013)

Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways
por: Wang, Chih-Ya, et al.
Publicado: (2012)

Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways
por: Stump, Benjamin, et al.
Publicado: (2019)

LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling
por: Qiu, Yan-Song, et al.
Publicado: (2018)

20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
por: Lin, Kaili, et al.
Publicado: (2020)

URG4 mediates cell proliferation and cell cycle in osteosarcoma via GSK3β/β-catenin/cyclin D1 signaling pathway
por: Liu, Yayun, et al.
Publicado: (2020)

mTOR regulates brain morphogenesis by mediating GSK3 signaling
por: Ka, Minhan, et al.
Publicado: (2014)

Fluoxetine Regulates Neurogenesis In Vitro Through Modulation of GSK-3β/β-Catenin Signaling
por: Hui, Jiaojie, et al.
Publicado: (2015)

Number 2 Feibi Recipe Ameliorates Pulmonary Fibrosis by Inducing Autophagy Through the GSK-3β/mTOR Pathway
por: Liu, Haoge, et al.
Publicado: (2022)

NLRP3 augmented resistance to gemcitabine in triple-negative breast cancer cells via EMT/IL-1β/Wnt/β-catenin signaling pathway
por: Zheng, Qiao, et al.
Publicado: (2020)

Astaxanthin suppresses lipopolysaccharide-induced myocardial injury by regulating MAPK and PI3K/AKT/mTOR/GSK3β signaling
por: Xie, Wen-Jie, et al.
Publicado: (2020)

Resveratrol protects against apoptosis induced by interleukin-1β in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3β/caspase-3 pathways
por: Guo, Xiaohui, et al.
Publicado: (2020)

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway
por: Zuo, Qiang, et al.
Publicado: (2021)

The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3β/β-Catenin/cyclinD1 Signaling Pathway
por: Li, Shijie, et al.
Publicado: (2017)

Estrogen receptor β induces autophagy of osteosarcoma through the mTOR signaling pathway
por: Yang, Zhengming, et al.
Publicado: (2020)

Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β
por: Mennerich, Daniela, et al.
Publicado: (2014)

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
por: Maher, Meghan T., et al.
Publicado: (2010)

Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway
por: Liu, Weihai, et al.
Publicado: (2018)

Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β
por: Rask, K, et al.
Publicado: (2003)

Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT/GSK3 β/β‐catenin pathways
por: Yan, De‐Yi, et al.
Publicado: (2019)

Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling
por: Wang, Yun, et al.
Publicado: (2023)

Suxiao Jiuxin Pill alleviates myocardial ischemia–reperfusion injury through the ALKBH5/GSK3β/mTOR pathway
por: Li, Yiping, et al.
Publicado: (2023)

Retraction: Resveratrol protects against apoptosis induced by interleukin-1β in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3β/caspase-3 pathway
Publicado: (2020)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase
por: Mai, Wei, et al.
Publicado: (2021)

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
por: Arend, Rebecca C., et al.
Publicado: (2016)

Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method
por: Sun, Ying-Chieh
Publicado: (2009)

Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS
por: Zeng, Xinxin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gu8ku4utp7l1fs4n5vrvv6g9d2