Identification of hepatitis B virus genotype I in Thailand

The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I ge...

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Detalles Bibliográficos
Autores principales: Holzmayer, Vera, Hance, Robert, Defechereux, Patricia, Grant, Robert, Kuhns, Mary C., Cloherty, Gavin, Rodgers, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618046/
https://www.ncbi.nlm.nih.gov/pubmed/30351478
http://dx.doi.org/10.1002/jmv.25346
Descripción
Sumario:The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV‐I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV‐I classification as a unique genotype.

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