Identification of hepatitis B virus genotype I in Thailand

The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I ge...

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Autores principales: Holzmayer, Vera, Hance, Robert, Defechereux, Patricia, Grant, Robert, Kuhns, Mary C., Cloherty, Gavin, Rodgers, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618046/
https://www.ncbi.nlm.nih.gov/pubmed/30351478
http://dx.doi.org/10.1002/jmv.25346
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author Holzmayer, Vera
Hance, Robert
Defechereux, Patricia
Grant, Robert
Kuhns, Mary C.
Cloherty, Gavin
Rodgers, Mary A.
author_facet Holzmayer, Vera
Hance, Robert
Defechereux, Patricia
Grant, Robert
Kuhns, Mary C.
Cloherty, Gavin
Rodgers, Mary A.
author_sort Holzmayer, Vera
collection PubMed
description The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV‐I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV‐I classification as a unique genotype.
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spelling pubmed-66180462019-07-22 Identification of hepatitis B virus genotype I in Thailand Holzmayer, Vera Hance, Robert Defechereux, Patricia Grant, Robert Kuhns, Mary C. Cloherty, Gavin Rodgers, Mary A. J Med Virol Short Communications The rare hepatitis B virus genotype I (HBV‐I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV‐I specimen from Thailand, with detectable HBsAg despite a 10–amino‐acid truncation. This HBV‐I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV‐I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV‐I classification as a unique genotype. John Wiley and Sons Inc. 2018-11-08 2019-04 /pmc/articles/PMC6618046/ /pubmed/30351478 http://dx.doi.org/10.1002/jmv.25346 Text en © 2018 The Authors. Journal of Medical Virology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Holzmayer, Vera
Hance, Robert
Defechereux, Patricia
Grant, Robert
Kuhns, Mary C.
Cloherty, Gavin
Rodgers, Mary A.
Identification of hepatitis B virus genotype I in Thailand
title Identification of hepatitis B virus genotype I in Thailand
title_full Identification of hepatitis B virus genotype I in Thailand
title_fullStr Identification of hepatitis B virus genotype I in Thailand
title_full_unstemmed Identification of hepatitis B virus genotype I in Thailand
title_short Identification of hepatitis B virus genotype I in Thailand
title_sort identification of hepatitis b virus genotype i in thailand
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618046/
https://www.ncbi.nlm.nih.gov/pubmed/30351478
http://dx.doi.org/10.1002/jmv.25346
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