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IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA). We tested the hypothesis that transcriptional “imprinting” of T-cells by...

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Detalles Bibliográficos
Autores principales:	Ridgley, Laura A., Anderson, Amy E., Maney, Nicola J., Naamane, Najib, Skelton, Andrew J., Lawson, Catherine A., Emery, Paul, Isaacs, John D., Carmody, Ruaidhrí J., Pratt, Arthur G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618050/ https://www.ncbi.nlm.nih.gov/pubmed/31333666 http://dx.doi.org/10.3389/fimmu.2019.01535

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