Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches

The application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different discipl...

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Autores principales: Schmidt, Stephan, Kim, Sarah, Vozmediano, Valvanera, Cristofoletti, Rodrigo, Winterstein, Almut G., Brown, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618101/
https://www.ncbi.nlm.nih.gov/pubmed/31179639
http://dx.doi.org/10.1002/psp4.12425
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author Schmidt, Stephan
Kim, Sarah
Vozmediano, Valvanera
Cristofoletti, Rodrigo
Winterstein, Almut G.
Brown, Joshua D.
author_facet Schmidt, Stephan
Kim, Sarah
Vozmediano, Valvanera
Cristofoletti, Rodrigo
Winterstein, Almut G.
Brown, Joshua D.
author_sort Schmidt, Stephan
collection PubMed
description The application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different disciplines may bridge between preclinical and clinical drug development as well as between academic curiosity and clinical practice. Herein we review the history and present the state of M&S approaches as well as our vision for future challenges and applications.
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spelling pubmed-66181012019-07-16 Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches Schmidt, Stephan Kim, Sarah Vozmediano, Valvanera Cristofoletti, Rodrigo Winterstein, Almut G. Brown, Joshua D. CPT Pharmacometrics Syst Pharmacol Perspectives The application of modeling and simulation (M&S) tools to biological, physiological, and clinical data has great potential to enhance drug development and regulatory decision making. The strategic development of multidisciplinary projects aimed at integrating methodologies from different disciplines may bridge between preclinical and clinical drug development as well as between academic curiosity and clinical practice. Herein we review the history and present the state of M&S approaches as well as our vision for future challenges and applications. John Wiley and Sons Inc. 2019-06-09 2019-06 /pmc/articles/PMC6618101/ /pubmed/31179639 http://dx.doi.org/10.1002/psp4.12425 Text en © 2019 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspectives
Schmidt, Stephan
Kim, Sarah
Vozmediano, Valvanera
Cristofoletti, Rodrigo
Winterstein, Almut G.
Brown, Joshua D.
Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title_full Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title_fullStr Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title_full_unstemmed Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title_short Pharmacometrics, Physiologically Based Pharmacokinetics, Quantitative Systems Pharmacology—What's Next?—Joining Mechanistic and Epidemiological Approaches
title_sort pharmacometrics, physiologically based pharmacokinetics, quantitative systems pharmacology—what's next?—joining mechanistic and epidemiological approaches
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618101/
https://www.ncbi.nlm.nih.gov/pubmed/31179639
http://dx.doi.org/10.1002/psp4.12425
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