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Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature

Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant refractory to many conventional treatments. We report the successful treatment with secukinumab of a patient with a long history of ACH with marked onychodystrophy with frank pustulosis on the nail bed and with accompany...

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Autores principales: Galluzzo, Marco, D'Adamio, Simone, Teoli, Miriam, Bianchi, Luca, Talamonti, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618131/
https://www.ncbi.nlm.nih.gov/pubmed/30969010
http://dx.doi.org/10.1111/dth.12899
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author Galluzzo, Marco
D'Adamio, Simone
Teoli, Miriam
Bianchi, Luca
Talamonti, Marina
author_facet Galluzzo, Marco
D'Adamio, Simone
Teoli, Miriam
Bianchi, Luca
Talamonti, Marina
author_sort Galluzzo, Marco
collection PubMed
description Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant refractory to many conventional treatments. We report the successful treatment with secukinumab of a patient with a long history of ACH with marked onychodystrophy with frank pustulosis on the nail bed and with accompanying arthritis. Blockade of the IL‐17 receptor A has shown promise in the treatment of psoriatic erythroderma and generalized pustular psoriasis not responsive to conventional treatment. A rapid response was observed in our patient, in both skin lesions and arthritic symptoms, underlining the ability of secukinumab to improve symptoms beyond those of plaque psoriasis.
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spelling pubmed-66181312019-07-22 Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature Galluzzo, Marco D'Adamio, Simone Teoli, Miriam Bianchi, Luca Talamonti, Marina Dermatol Ther Therapeutic Hotline: Short Papers Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant refractory to many conventional treatments. We report the successful treatment with secukinumab of a patient with a long history of ACH with marked onychodystrophy with frank pustulosis on the nail bed and with accompanying arthritis. Blockade of the IL‐17 receptor A has shown promise in the treatment of psoriatic erythroderma and generalized pustular psoriasis not responsive to conventional treatment. A rapid response was observed in our patient, in both skin lesions and arthritic symptoms, underlining the ability of secukinumab to improve symptoms beyond those of plaque psoriasis. John Wiley & Sons, Inc. 2019-04-29 2019 /pmc/articles/PMC6618131/ /pubmed/30969010 http://dx.doi.org/10.1111/dth.12899 Text en © 2019 The Authors. Dermatologic Therapy published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Therapeutic Hotline: Short Papers
Galluzzo, Marco
D'Adamio, Simone
Teoli, Miriam
Bianchi, Luca
Talamonti, Marina
Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title_full Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title_fullStr Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title_full_unstemmed Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title_short Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature
title_sort biologic therapy for acrodermatitis continua of hallopeau: successful treatment with secukinumab and review of the literature
topic Therapeutic Hotline: Short Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618131/
https://www.ncbi.nlm.nih.gov/pubmed/30969010
http://dx.doi.org/10.1111/dth.12899
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