Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability

Lugdunin, a novel thiazolidine cyclopeptide, exhibits micromolar activity against methicillin‐resistant Staphylococcus aureus (MRSA). For structure–activity relationship (SAR) studies, synthetic analogues obtained from alanine and stereo scanning as well as peptides with modified thiazolidine rings...

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Detalles Bibliográficos
Autores principales: Schilling, Nadine A., Berscheid, Anne, Schumacher, Johannes, Saur, Julian S., Konnerth, Martin C., Wirtz, Sebastian N., Beltrán‐Beleña, José M., Zipperer, Alexander, Krismer, Bernhard, Peschel, Andreas, Kalbacher, Hubert, Brötz‐Oesterhelt, Heike, Steinem, Claudia, Grond, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618241/
https://www.ncbi.nlm.nih.gov/pubmed/31059155
http://dx.doi.org/10.1002/anie.201901589

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