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Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
Multiple targeted therapeutics for Huntington's disease are now in clinical trials, including intrathecally delivered compounds. Previous research suggests that CSF dynamics may be altered in Huntington's disease, which could be of paramount relevance to intrathecal drug delivery to the br...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618296/ https://www.ncbi.nlm.nih.gov/pubmed/30687961 http://dx.doi.org/10.1111/ejn.14356 |
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author | Rodrigues, Filipe B. Byrne, Lauren M. De Vita, Enrico Johnson, Eileanoir B. Hobbs, Nicola Z. Thornton, John S. Scahill, Rachael I. Wild, Edward J. |
author_facet | Rodrigues, Filipe B. Byrne, Lauren M. De Vita, Enrico Johnson, Eileanoir B. Hobbs, Nicola Z. Thornton, John S. Scahill, Rachael I. Wild, Edward J. |
author_sort | Rodrigues, Filipe B. |
collection | PubMed |
description | Multiple targeted therapeutics for Huntington's disease are now in clinical trials, including intrathecally delivered compounds. Previous research suggests that CSF dynamics may be altered in Huntington's disease, which could be of paramount relevance to intrathecal drug delivery to the brain. To test this hypothesis, we conducted a prospective cross‐sectional study comparing people with early stage Huntington's disease with age‐ and gender‐matched healthy controls. CSF peak velocity, mean velocity and mean flow at the level of the cerebral aqueduct, and sub‐arachnoid space in the upper and lower spine, were quantified using phase contrast MRI. We calculated Spearman's rank correlations, and tested inter‐group differences with Wilcoxon rank‐sum test. Ten people with early Huntington's disease, and 10 controls were included. None of the quantified measures was associated with potential modifiers of CSF dynamics (demographics, osmolality, and brain volumes), or by known modifiers of Huntington's disease (age and HTT CAG repeat length); and no significant differences were found between the two studied groups. While external validation is required, the attained results are sufficient to conclude tentatively that a clinically relevant alteration of CSF dynamics – that is, one that would justify dose‐adjustments of intrathecal drugs – is unlikely to exist in Huntington's disease. |
format | Online Article Text |
id | pubmed-6618296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66182962019-07-22 Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI Rodrigues, Filipe B. Byrne, Lauren M. De Vita, Enrico Johnson, Eileanoir B. Hobbs, Nicola Z. Thornton, John S. Scahill, Rachael I. Wild, Edward J. Eur J Neurosci Clinical and Translational Neuroscience Multiple targeted therapeutics for Huntington's disease are now in clinical trials, including intrathecally delivered compounds. Previous research suggests that CSF dynamics may be altered in Huntington's disease, which could be of paramount relevance to intrathecal drug delivery to the brain. To test this hypothesis, we conducted a prospective cross‐sectional study comparing people with early stage Huntington's disease with age‐ and gender‐matched healthy controls. CSF peak velocity, mean velocity and mean flow at the level of the cerebral aqueduct, and sub‐arachnoid space in the upper and lower spine, were quantified using phase contrast MRI. We calculated Spearman's rank correlations, and tested inter‐group differences with Wilcoxon rank‐sum test. Ten people with early Huntington's disease, and 10 controls were included. None of the quantified measures was associated with potential modifiers of CSF dynamics (demographics, osmolality, and brain volumes), or by known modifiers of Huntington's disease (age and HTT CAG repeat length); and no significant differences were found between the two studied groups. While external validation is required, the attained results are sufficient to conclude tentatively that a clinically relevant alteration of CSF dynamics – that is, one that would justify dose‐adjustments of intrathecal drugs – is unlikely to exist in Huntington's disease. John Wiley and Sons Inc. 2019-02-19 2019-06 /pmc/articles/PMC6618296/ /pubmed/30687961 http://dx.doi.org/10.1111/ejn.14356 Text en © 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical and Translational Neuroscience Rodrigues, Filipe B. Byrne, Lauren M. De Vita, Enrico Johnson, Eileanoir B. Hobbs, Nicola Z. Thornton, John S. Scahill, Rachael I. Wild, Edward J. Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI |
title | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
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title_full | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
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title_fullStr | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
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title_full_unstemmed | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
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title_short | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
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title_sort | cerebrospinal fluid flow dynamics in huntington's disease evaluated by phase contrast mri |
topic | Clinical and Translational Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618296/ https://www.ncbi.nlm.nih.gov/pubmed/30687961 http://dx.doi.org/10.1111/ejn.14356 |
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