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Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1

Malformin A1 (MA1) is a fungus‐produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis‐enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the cytotoxicity of MA1 in monocytoid U937 cells...

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Detalles Bibliográficos
Autores principales:	Koizumi, Yukio, Fukushima, Jun, Kobayashi, Yayoi, Kadowaki, Ayumi, Natsui, Miyuki, Yamaguchi, Tomokazu, Imai, Yumiko, Sugiyama, Toshihiro, Kuba, Keiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618319/ https://www.ncbi.nlm.nih.gov/pubmed/30734978 http://dx.doi.org/10.1002/cbic.201800769

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