Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer

Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the asso...

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Detalles Bibliográficos
Autores principales: Lee, Seul A., Liu, Fang, Riordan, Stephen M., Lee, Cheok S., Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618585/
https://www.ncbi.nlm.nih.gov/pubmed/31334107
http://dx.doi.org/10.3389/fonc.2019.00566
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author Lee, Seul A.
Liu, Fang
Riordan, Stephen M.
Lee, Cheok S.
Zhang, Li
author_facet Lee, Seul A.
Liu, Fang
Riordan, Stephen M.
Lee, Cheok S.
Zhang, Li
author_sort Lee, Seul A.
collection PubMed
description Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions.
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spelling pubmed-66185852019-07-22 Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer Lee, Seul A. Liu, Fang Riordan, Stephen M. Lee, Cheok S. Zhang, Li Front Oncol Oncology Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions. Frontiers Media S.A. 2019-07-03 /pmc/articles/PMC6618585/ /pubmed/31334107 http://dx.doi.org/10.3389/fonc.2019.00566 Text en Copyright © 2019 Lee, Liu, Riordan, Lee and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lee, Seul A.
Liu, Fang
Riordan, Stephen M.
Lee, Cheok S.
Zhang, Li
Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title_full Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title_fullStr Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title_full_unstemmed Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title_short Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
title_sort global investigations of fusobacterium nucleatum in human colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618585/
https://www.ncbi.nlm.nih.gov/pubmed/31334107
http://dx.doi.org/10.3389/fonc.2019.00566
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