Cargando…

An Open‐Label, Single‐Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults

Amenamevir is an inhibitor of the helicase‐primase enzyme complex developed for the treatment of varicella zoster virus. This mass balance study investigated the absorption, metabolism, and excretion of a single dose (200 mg) of (14)C‐labeled amenamevir in healthy male volunteers. Blood, urine, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kato, Kota, den Adel, Martin, Groenendaal‐van de Meent, Dorien, Ohtsu, Yoshiaki, Takada, Akitsugu, Katashima, Masataka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619336/ https://www.ncbi.nlm.nih.gov/pubmed/30412362 http://dx.doi.org/10.1002/cpdd.630

Ejemplares similares

Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults
por: Kusawake, Tomohiro, et al.
Publicado: (2017)

Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies
por: Kusawake, Tomohiro, et al.
Publicado: (2017)

The Influence of Hepatic and Renal Impairment on the Pharmacokinetics of a Treatment for Herpes Zoster, Amenamevir (ASP2151): Phase 1, Open-Label, Single-Dose, Parallel-Group Studies
por: Kusawake, Tomohiro, et al.
Publicado: (2017)

Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies
por: Groenendaal‐van de Meent, Dorien, et al.
Publicado: (2022)

Population pharmacokinetics of roxadustat in Japanese dialysis‐dependent chronic kidney disease patients with anaemia
por: Takada, Akitsugu, et al.
Publicado: (2021)

Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents
por: Ohtsu, Yoshiaki, et al.
Publicado: (2018)

Evaluation of Food and Spherical Carbon Adsorbent Effects on the Pharmacokinetics of Roxadustat in Healthy Nonelderly Adult Male Japanese Subjects
por: Shibata, Tomohisa, et al.
Publicado: (2018)

Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects
por: Groenendaal-van de Meent, Dorien, et al.
Publicado: (2018)

Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of (14)C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers
por: Townsend, Robert, et al.
Publicado: (2017)

Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma
por: Aoyama, Yumiko, et al.
Publicado: (2012)

Amenamevir, a Helicase-Primase Inhibitor, for the Optimal Treatment of Herpes Zoster
por: Shiraki, Kimiyasu, et al.
Publicado: (2021)

Amenamevir: Studies of Potential CYP3A‐Mediated Pharmacokinetic Interactions With Midazolam, Cyclosporine, and Ritonavir in Healthy Volunteers
por: Adeloye, Temitope, et al.
Publicado: (2018)

Effect of Kidney Function and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
por: Groenendaal-van de Meent, Dorien, et al.
Publicado: (2020)

A 1-Year Survey of Zoster-Associated Pain after Amenamevir Treatment
por: Kawashima, Makoto, et al.
Publicado: (2022)

Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
por: Groenendaal-van de Meent, Dorien, et al.
Publicado: (2016)

Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
por: Itoh, Kazuhiro, et al.
Publicado: (2022)

Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialysis Patients
por: Tsuruoka, Shuichi, et al.
Publicado: (2020)

Amenamevir: Studies of Potential CYP2C8‐ and CYP2B6‐Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers
por: Dennison, Jeremy, et al.
Publicado: (2018)

Correction to: Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialysis Patients
por: Tsuruoka, Shuichi, et al.
Publicado: (2020)

The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient
por: Kobayashi, Hiroki, et al.
Publicado: (2021)

Amenamevir, a novel helicase–primase inhibitor, for treatment of herpes zoster: A randomized, double‐blind, valaciclovir‐controlled phase 3 study
por: Kawashima, Makoto, et al.
Publicado: (2017)

Single-Dose, Patient-Initiated Amenamevir Therapy for Recurrent Genital Herpes: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study
por: Kawashima, Makoto, et al.
Publicado: (2022)

Pharmacokinetics of Mirabegron, a β(3)-Adrenoceptor Agonist for Treatment of Overactive Bladder, in Healthy Japanese Male Subjects: Results from Single- and Multiple-Dose Studies
por: Iitsuka, Hiromi, et al.
Publicado: (2013)

Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers
por: Lee, Moon Hee, et al.
Publicado: (2023)

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers
por: Kim, Yo Han, et al.
Publicado: (2015)

Effect of footwear on standing balance in healthy young adult males
por: Alghadir, Ahmad H., et al.
Publicado: (2018)

An open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy males
por: Oben, Julius, et al.
Publicado: (2008)

Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers
por: Kim, Hyungsub, et al.
Publicado: (2018)

Preseason Dynamic Balance Performance in Healthy Elite Male Soccer Players
por: Onofrei, Roxana-Ramona, et al.
Publicado: (2019)

An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males
por: Angwafor, Fru, et al.
Publicado: (2008)

Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers
por: Kim, Hyungsub, et al.
Publicado: (2022)

Pharmacokinetic interaction of voriconazole and clarithromycin in Pakistani healthy male volunteers: a single dose, randomized, crossover, open-label study
por: Mushtaq, Mehwish, et al.
Publicado: (2023)

Platform for Analysis and Labeling of Medical Time Series
por: Fedjajevs, Andrejs, et al.
Publicado: (2020)

Orally Formulated Artemisinin in Healthy Fasting Vietnamese Male Subjects: A Randomized, Four-Sequence, Open-Label, Pharmacokinetic Crossover Study
por: Hien, Tran Tinh, et al.
Publicado: (2011)

Open-label, single-center, phase I trial to investigate the mass balance and absolute bioavailability of the highly selective oral MET inhibitor tepotinib in healthy volunteers
por: Johne, Andreas, et al.
Publicado: (2020)

An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects
por: Evans, Malkanthi, et al.
Publicado: (2014)

Comparison of a Novel Formulation of Abiraterone Acetate vs. the Originator Formulation in Healthy Male Subjects: Two Randomized, Open-Label, Crossover Studies
por: Goldwater, Ronald, et al.
Publicado: (2017)

An Open-Label, Randomized, Single-Dose, Crossover, Comparative Pharmacokinetics Study of YLB113 and the Etanercept Reference Product in Healthy Adult Male Subjects
por: Shennak, Mustafa, et al.
Publicado: (2020)

Self-Assessed Benefits of a Prostate Health Formulation on Nocturia in Healthy Males With Mild Lower Urinary Tract Symptoms: An Open Label Study
por: Hirsh, Steven P, et al.
Publicado: (2020)

Effect of quadriceps and calf muscles fatigue on standing balance in healthy young adult males
por: Joudeh, Ali A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_otibn2t3p1rst3sqchbfbkj41p