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Metachronous or synchronous male breast and prostate cancers a duality to lookout for.

Introduction: Breast cancer is well known as the stereotypical women's cancer, and prostate cancer represents the well-known stereotypical male counterpart. While prostate cancer carries the potential to metastasize to the breast, the synchronous or metachronous co-occurrence of primary breast...

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Autores principales: Mukendi, Alain Mwamba, Van Den Berg, Eunice, Pather, Sugeshnee, Padayachee, Rushen Siva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619383/
https://www.ncbi.nlm.nih.gov/pubmed/31431822
http://dx.doi.org/10.12688/f1000research.16997.2
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author Mukendi, Alain Mwamba
Van Den Berg, Eunice
Pather, Sugeshnee
Padayachee, Rushen Siva
author_facet Mukendi, Alain Mwamba
Van Den Berg, Eunice
Pather, Sugeshnee
Padayachee, Rushen Siva
author_sort Mukendi, Alain Mwamba
collection PubMed
description Introduction: Breast cancer is well known as the stereotypical women's cancer, and prostate cancer represents the well-known stereotypical male counterpart. While prostate cancer carries the potential to metastasize to the breast, the synchronous or metachronous co-occurrence of primary breast and primary prostate cancers is quite unusual. Prostate cancer in men of African descent may have its own behaviour with regards to its relationship with male breast cancer. Case presentation: Case 1: A 64 year old male presented to Chris Hani Baragwanath Hospital (CHBAH) with a 2 years history of a painless left breast lump. A core biopsy was done and confirmed breast carcinoma. Tamoxifen was started but, due to disease progression, he underwent left modified radical mastectomy followed by chemotherapy. Prostate biopsy was done for raised Prostate Specific Antigen (PSA) and suspicious prostate on digital rectal examination. A prostatic adenocarcinoma was subsequently diagnosed with bone metastases on bone scan. He was started on Androgen deprivation therapy and followed up every 3 months. Case 2: A 68 year old male presented to CHBAH with a 1 year history of a painless right breast lump. A core biopsy confirmed breast cancer. Tamoxifen was started, followed by right modified radical mastectomy and chemotherapy for disease progression. A raised PSA and suspicious prostate on digital rectal examination prompted a prostate biopsy revealing a prostatic adenocarcinoma. Bone scan was negative for metastasis. He is currently on 3 monthly Androgen deprivation therapy and awaiting radiation. Conclusion: This clinical practice article not only presents this exceptionally rare duality but highlights that both cancers can coexist either as sporadic conditions, or as a result of genetic mutations. Thus, we suggest that men with prostate cancer be screened clinically, biochemically and genetically for breast cancer and vice versa.
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spelling pubmed-66193832019-08-19 Metachronous or synchronous male breast and prostate cancers a duality to lookout for. Mukendi, Alain Mwamba Van Den Berg, Eunice Pather, Sugeshnee Padayachee, Rushen Siva F1000Res Clinical Practice Article Introduction: Breast cancer is well known as the stereotypical women's cancer, and prostate cancer represents the well-known stereotypical male counterpart. While prostate cancer carries the potential to metastasize to the breast, the synchronous or metachronous co-occurrence of primary breast and primary prostate cancers is quite unusual. Prostate cancer in men of African descent may have its own behaviour with regards to its relationship with male breast cancer. Case presentation: Case 1: A 64 year old male presented to Chris Hani Baragwanath Hospital (CHBAH) with a 2 years history of a painless left breast lump. A core biopsy was done and confirmed breast carcinoma. Tamoxifen was started but, due to disease progression, he underwent left modified radical mastectomy followed by chemotherapy. Prostate biopsy was done for raised Prostate Specific Antigen (PSA) and suspicious prostate on digital rectal examination. A prostatic adenocarcinoma was subsequently diagnosed with bone metastases on bone scan. He was started on Androgen deprivation therapy and followed up every 3 months. Case 2: A 68 year old male presented to CHBAH with a 1 year history of a painless right breast lump. A core biopsy confirmed breast cancer. Tamoxifen was started, followed by right modified radical mastectomy and chemotherapy for disease progression. A raised PSA and suspicious prostate on digital rectal examination prompted a prostate biopsy revealing a prostatic adenocarcinoma. Bone scan was negative for metastasis. He is currently on 3 monthly Androgen deprivation therapy and awaiting radiation. Conclusion: This clinical practice article not only presents this exceptionally rare duality but highlights that both cancers can coexist either as sporadic conditions, or as a result of genetic mutations. Thus, we suggest that men with prostate cancer be screened clinically, biochemically and genetically for breast cancer and vice versa. F1000 Research Limited 2019-02-26 /pmc/articles/PMC6619383/ /pubmed/31431822 http://dx.doi.org/10.12688/f1000research.16997.2 Text en Copyright: © 2019 Mukendi AM et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Practice Article
Mukendi, Alain Mwamba
Van Den Berg, Eunice
Pather, Sugeshnee
Padayachee, Rushen Siva
Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title_full Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title_fullStr Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title_full_unstemmed Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title_short Metachronous or synchronous male breast and prostate cancers a duality to lookout for.
title_sort metachronous or synchronous male breast and prostate cancers a duality to lookout for.
topic Clinical Practice Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619383/
https://www.ncbi.nlm.nih.gov/pubmed/31431822
http://dx.doi.org/10.12688/f1000research.16997.2
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