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The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency
BACKGROUND: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationsh...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619469/ https://www.ncbi.nlm.nih.gov/pubmed/31363390 http://dx.doi.org/10.22088/cjim.10.2.125 |
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author | Hajhashemi, Maryam Ansari, Maryam Haghollahi, Fedyeh Eslami, Bita |
author_facet | Hajhashemi, Maryam Ansari, Maryam Haghollahi, Fedyeh Eslami, Bita |
author_sort | Hajhashemi, Maryam |
collection | PubMed |
description | BACKGROUND: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin D and uterine leiomyomas(.) The aim of this study was to evaluate the effect of vit D supplementation on the size of uterine leiomyoma in women with vit D deficiency. METHODS: This double-blind prospective clinical trial was performed on 69 patients with uterine leiomyomas who had vit D deficiency. Group A (n=35) was treated with vit D 50,000 IU every 2 weeks for 10 weeks, while group B (n=34) received placebo with same color and shape. Finally, the leiomyoma size in both groups was compared (IRCT: 20160521027998N5). RESULTS: After a 10-week intervention, 25-hydroxyvitamin D(3) levels were significantly higher in group receiving vitamin D (36.08 vs 16.25 ng/ml). (P<0.001) Leiomyomas size in vit D group significantly decreased as compared to placebo group (52.58 vs 61.11 mm, respectively). CONCLUSION: Our results showed that administration of vit D3 may reduce the size of leiomyoma. It seems that vitamin D administration is the effective way to treat leiomyoma. |
format | Online Article Text |
id | pubmed-6619469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-66194692019-07-30 The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency Hajhashemi, Maryam Ansari, Maryam Haghollahi, Fedyeh Eslami, Bita Caspian J Intern Med Original Article BACKGROUND: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin D and uterine leiomyomas(.) The aim of this study was to evaluate the effect of vit D supplementation on the size of uterine leiomyoma in women with vit D deficiency. METHODS: This double-blind prospective clinical trial was performed on 69 patients with uterine leiomyomas who had vit D deficiency. Group A (n=35) was treated with vit D 50,000 IU every 2 weeks for 10 weeks, while group B (n=34) received placebo with same color and shape. Finally, the leiomyoma size in both groups was compared (IRCT: 20160521027998N5). RESULTS: After a 10-week intervention, 25-hydroxyvitamin D(3) levels were significantly higher in group receiving vitamin D (36.08 vs 16.25 ng/ml). (P<0.001) Leiomyomas size in vit D group significantly decreased as compared to placebo group (52.58 vs 61.11 mm, respectively). CONCLUSION: Our results showed that administration of vit D3 may reduce the size of leiomyoma. It seems that vitamin D administration is the effective way to treat leiomyoma. Babol University of Medical Sciences 2019 /pmc/articles/PMC6619469/ /pubmed/31363390 http://dx.doi.org/10.22088/cjim.10.2.125 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hajhashemi, Maryam Ansari, Maryam Haghollahi, Fedyeh Eslami, Bita The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title | The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title_full | The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title_fullStr | The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title_full_unstemmed | The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title_short | The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency |
title_sort | effect of vitamin d supplementation on the size of uterine leiomyoma in women with vitamin d deficiency |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619469/ https://www.ncbi.nlm.nih.gov/pubmed/31363390 http://dx.doi.org/10.22088/cjim.10.2.125 |
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