Cargando…

Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis

AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Morishita, Michiko, Sada, Ken-Ei, Matsumoto, Yoshinori, Hayashi, Keigo, Asano, Yosuke, Hiramatsu Asano, Sumie, Ohashi, Keiji, Miyawaki, Yoshia, Katsuyama, Eri, Watanabe, Haruki, Kawabata, Tomoko, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619987/
https://www.ncbi.nlm.nih.gov/pubmed/31291263
http://dx.doi.org/10.1371/journal.pone.0218705
_version_ 1783433974355329024
author Morishita, Michiko
Sada, Ken-Ei
Matsumoto, Yoshinori
Hayashi, Keigo
Asano, Yosuke
Hiramatsu Asano, Sumie
Ohashi, Keiji
Miyawaki, Yoshia
Katsuyama, Eri
Watanabe, Haruki
Kawabata, Tomoko
Wada, Jun
author_facet Morishita, Michiko
Sada, Ken-Ei
Matsumoto, Yoshinori
Hayashi, Keigo
Asano, Yosuke
Hiramatsu Asano, Sumie
Ohashi, Keiji
Miyawaki, Yoshia
Katsuyama, Eri
Watanabe, Haruki
Kawabata, Tomoko
Wada, Jun
author_sort Morishita, Michiko
collection PubMed
description AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. RESULTS: Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). CONCLUSION: Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection.
format Online
Article
Text
id pubmed-6619987
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66199872019-07-25 Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis Morishita, Michiko Sada, Ken-Ei Matsumoto, Yoshinori Hayashi, Keigo Asano, Yosuke Hiramatsu Asano, Sumie Ohashi, Keiji Miyawaki, Yoshia Katsuyama, Eri Watanabe, Haruki Kawabata, Tomoko Wada, Jun PLoS One Research Article AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. RESULTS: Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). CONCLUSION: Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection. Public Library of Science 2019-07-10 /pmc/articles/PMC6619987/ /pubmed/31291263 http://dx.doi.org/10.1371/journal.pone.0218705 Text en © 2019 Morishita et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Morishita, Michiko
Sada, Ken-Ei
Matsumoto, Yoshinori
Hayashi, Keigo
Asano, Yosuke
Hiramatsu Asano, Sumie
Ohashi, Keiji
Miyawaki, Yoshia
Katsuyama, Eri
Watanabe, Haruki
Kawabata, Tomoko
Wada, Jun
Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title_full Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title_fullStr Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title_full_unstemmed Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title_short Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
title_sort risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619987/
https://www.ncbi.nlm.nih.gov/pubmed/31291263
http://dx.doi.org/10.1371/journal.pone.0218705
work_keys_str_mv AT morishitamichiko riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT sadakenei riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT matsumotoyoshinori riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT hayashikeigo riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT asanoyosuke riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT hiramatsuasanosumie riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT ohashikeiji riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT miyawakiyoshia riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT katsuyamaeri riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT watanabeharuki riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT kawabatatomoko riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis
AT wadajun riskfactorsforcytomegalovirusinfectioninpatientswithantineutrophilcytoplasmicantibodyassociatedvasculitis