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Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis
AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619987/ https://www.ncbi.nlm.nih.gov/pubmed/31291263 http://dx.doi.org/10.1371/journal.pone.0218705 |
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author | Morishita, Michiko Sada, Ken-Ei Matsumoto, Yoshinori Hayashi, Keigo Asano, Yosuke Hiramatsu Asano, Sumie Ohashi, Keiji Miyawaki, Yoshia Katsuyama, Eri Watanabe, Haruki Kawabata, Tomoko Wada, Jun |
author_facet | Morishita, Michiko Sada, Ken-Ei Matsumoto, Yoshinori Hayashi, Keigo Asano, Yosuke Hiramatsu Asano, Sumie Ohashi, Keiji Miyawaki, Yoshia Katsuyama, Eri Watanabe, Haruki Kawabata, Tomoko Wada, Jun |
author_sort | Morishita, Michiko |
collection | PubMed |
description | AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. RESULTS: Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). CONCLUSION: Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection. |
format | Online Article Text |
id | pubmed-6619987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66199872019-07-25 Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis Morishita, Michiko Sada, Ken-Ei Matsumoto, Yoshinori Hayashi, Keigo Asano, Yosuke Hiramatsu Asano, Sumie Ohashi, Keiji Miyawaki, Yoshia Katsuyama, Eri Watanabe, Haruki Kawabata, Tomoko Wada, Jun PLoS One Research Article AIMS: Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. RESULTS: Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92–60.23, and OR = 7.46, 95% CI = 1.46–47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). CONCLUSION: Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection. Public Library of Science 2019-07-10 /pmc/articles/PMC6619987/ /pubmed/31291263 http://dx.doi.org/10.1371/journal.pone.0218705 Text en © 2019 Morishita et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Morishita, Michiko Sada, Ken-Ei Matsumoto, Yoshinori Hayashi, Keigo Asano, Yosuke Hiramatsu Asano, Sumie Ohashi, Keiji Miyawaki, Yoshia Katsuyama, Eri Watanabe, Haruki Kawabata, Tomoko Wada, Jun Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title | Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title_full | Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title_fullStr | Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title_full_unstemmed | Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title_short | Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
title_sort | risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619987/ https://www.ncbi.nlm.nih.gov/pubmed/31291263 http://dx.doi.org/10.1371/journal.pone.0218705 |
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