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Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population
INTRODUCTION: Just recently, it has been established that the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is linked to the pathogenesis and to the evolution of human cancers. Therefore, the present study was concerned with the investigation of an eventual association be...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620085/ https://www.ncbi.nlm.nih.gov/pubmed/31312309 http://dx.doi.org/10.11604/pamj.2019.32.197.15129 |
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author | Benenemissi, Ikram Hana Sifi, Karima Sahli, Lakhder Khalil Semmam, Ouarda Abadi, Noureddine Satta, Dalila |
author_facet | Benenemissi, Ikram Hana Sifi, Karima Sahli, Lakhder Khalil Semmam, Ouarda Abadi, Noureddine Satta, Dalila |
author_sort | Benenemissi, Ikram Hana |
collection | PubMed |
description | INTRODUCTION: Just recently, it has been established that the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is linked to the pathogenesis and to the evolution of human cancers. Therefore, the present study was concerned with the investigation of an eventual association between glioma and I/D polymorphism of the ACE gene. METHODS: The expression of ACE gene was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis in 36 Algerian patients with glioma and 195 healthy controls. RESULTS: In glioma cases, allelic frequencies and genotypes distribution of the ACE I/D polymorphism were different from controls cases. ACE DD genotype were highly presented in glioma cases (63.9%) than controls (33.8%) and conferred 3.64-fold risk for predisposition in glioma cases (vs ID genotype, p<0.001). Recessive model (ACE II + ID genotypes vs DD) was associated with a 72% reduced risk of glioma (OR = 0.28, 95% CI: 0.13-0.60, p <0.001). Per copy D allele frequency was found higher in glioma cases (79.2%) than in controls (63.3 %), OR = 2.20, 95% CI: 1.20 - 4.03, p = 0.009. CONCLUSION: The obtained data showed that the presence of the D allele might be a risk factor for the development of glioma. Further studies considering different ethnic groups with large samples are required to confirm this finding. |
format | Online Article Text |
id | pubmed-6620085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-66200852019-07-16 Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population Benenemissi, Ikram Hana Sifi, Karima Sahli, Lakhder Khalil Semmam, Ouarda Abadi, Noureddine Satta, Dalila Pan Afr Med J Research INTRODUCTION: Just recently, it has been established that the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism is linked to the pathogenesis and to the evolution of human cancers. Therefore, the present study was concerned with the investigation of an eventual association between glioma and I/D polymorphism of the ACE gene. METHODS: The expression of ACE gene was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis in 36 Algerian patients with glioma and 195 healthy controls. RESULTS: In glioma cases, allelic frequencies and genotypes distribution of the ACE I/D polymorphism were different from controls cases. ACE DD genotype were highly presented in glioma cases (63.9%) than controls (33.8%) and conferred 3.64-fold risk for predisposition in glioma cases (vs ID genotype, p<0.001). Recessive model (ACE II + ID genotypes vs DD) was associated with a 72% reduced risk of glioma (OR = 0.28, 95% CI: 0.13-0.60, p <0.001). Per copy D allele frequency was found higher in glioma cases (79.2%) than in controls (63.3 %), OR = 2.20, 95% CI: 1.20 - 4.03, p = 0.009. CONCLUSION: The obtained data showed that the presence of the D allele might be a risk factor for the development of glioma. Further studies considering different ethnic groups with large samples are required to confirm this finding. The African Field Epidemiology Network 2019-04-23 /pmc/articles/PMC6620085/ /pubmed/31312309 http://dx.doi.org/10.11604/pamj.2019.32.197.15129 Text en © Ikram Hana Benenemissi et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Benenemissi, Ikram Hana Sifi, Karima Sahli, Lakhder Khalil Semmam, Ouarda Abadi, Noureddine Satta, Dalila Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title | Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title_full | Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title_fullStr | Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title_full_unstemmed | Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title_short | Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population |
title_sort | angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an algerian population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620085/ https://www.ncbi.nlm.nih.gov/pubmed/31312309 http://dx.doi.org/10.11604/pamj.2019.32.197.15129 |
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