Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment

Type I interferons are highly potent cytokines essential for self-protection against tumors and infections. Deregulations of type I interferon signaling are associated with multiple diseases that require novel therapeutic options. Here, we identified the small molecule, IT1t, a previously described...

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Detalles Bibliográficos
Autores principales: Smith, Nikaïa, Rodero, Mathieu P., Bekaddour, Nassima, Bondet, Vincent, Ruiz-Blanco, Yasser B., Harms, Mirja, Mayer, Benjamin, Bader-Meunier, Brigitte, Quartier, Pierre, Bodemer, Christine, Baudouin, Véronique, Dieudonné, Yannick, Kirchhoff, Frank, Sanchez Garcia, Elsa, Charbit, Bruno, Leboulanger, Nicolas, Jahrsdörfer, Bernd, Richard, Yolande, Korganow, Anne-Sophie, Münch, Jan, Nisole, Sébastien, Duffy, Darragh, Herbeuval, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620093/
https://www.ncbi.nlm.nih.gov/pubmed/31309143
http://dx.doi.org/10.1126/sciadv.aav9019

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