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The difference in serum proteomes in schizophrenia and bipolar disorder
BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620192/ https://www.ncbi.nlm.nih.gov/pubmed/31291891 http://dx.doi.org/10.1186/s12864-019-5848-1 |
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author | Smirnova, Liudmila Seregin, Alexander Boksha, Irina Dmitrieva, Elena Simutkin, German Kornetova, Elena Savushkina, Olga Letova, Anastasia Bokhan, Nikolay Ivanova, Svetlana Zgoda, Victor |
author_facet | Smirnova, Liudmila Seregin, Alexander Boksha, Irina Dmitrieva, Elena Simutkin, German Kornetova, Elena Savushkina, Olga Letova, Anastasia Bokhan, Nikolay Ivanova, Svetlana Zgoda, Victor |
author_sort | Smirnova, Liudmila |
collection | PubMed |
description | BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocytes and cell growth. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12) and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p = 0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p = 0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71, 7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001, 4.11] ng/ml). CONCLUSIONS: Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-019-5848-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6620192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66201922019-07-22 The difference in serum proteomes in schizophrenia and bipolar disorder Smirnova, Liudmila Seregin, Alexander Boksha, Irina Dmitrieva, Elena Simutkin, German Kornetova, Elena Savushkina, Olga Letova, Anastasia Bokhan, Nikolay Ivanova, Svetlana Zgoda, Victor BMC Genomics Research BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocytes and cell growth. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12) and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p = 0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p = 0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71, 7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001, 4.11] ng/ml). CONCLUSIONS: Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-019-5848-1) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-11 /pmc/articles/PMC6620192/ /pubmed/31291891 http://dx.doi.org/10.1186/s12864-019-5848-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Smirnova, Liudmila Seregin, Alexander Boksha, Irina Dmitrieva, Elena Simutkin, German Kornetova, Elena Savushkina, Olga Letova, Anastasia Bokhan, Nikolay Ivanova, Svetlana Zgoda, Victor The difference in serum proteomes in schizophrenia and bipolar disorder |
title | The difference in serum proteomes in schizophrenia and bipolar disorder |
title_full | The difference in serum proteomes in schizophrenia and bipolar disorder |
title_fullStr | The difference in serum proteomes in schizophrenia and bipolar disorder |
title_full_unstemmed | The difference in serum proteomes in schizophrenia and bipolar disorder |
title_short | The difference in serum proteomes in schizophrenia and bipolar disorder |
title_sort | difference in serum proteomes in schizophrenia and bipolar disorder |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620192/ https://www.ncbi.nlm.nih.gov/pubmed/31291891 http://dx.doi.org/10.1186/s12864-019-5848-1 |
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