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The difference in serum proteomes in schizophrenia and bipolar disorder

BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins....

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Autores principales: Smirnova, Liudmila, Seregin, Alexander, Boksha, Irina, Dmitrieva, Elena, Simutkin, German, Kornetova, Elena, Savushkina, Olga, Letova, Anastasia, Bokhan, Nikolay, Ivanova, Svetlana, Zgoda, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620192/
https://www.ncbi.nlm.nih.gov/pubmed/31291891
http://dx.doi.org/10.1186/s12864-019-5848-1
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author Smirnova, Liudmila
Seregin, Alexander
Boksha, Irina
Dmitrieva, Elena
Simutkin, German
Kornetova, Elena
Savushkina, Olga
Letova, Anastasia
Bokhan, Nikolay
Ivanova, Svetlana
Zgoda, Victor
author_facet Smirnova, Liudmila
Seregin, Alexander
Boksha, Irina
Dmitrieva, Elena
Simutkin, German
Kornetova, Elena
Savushkina, Olga
Letova, Anastasia
Bokhan, Nikolay
Ivanova, Svetlana
Zgoda, Victor
author_sort Smirnova, Liudmila
collection PubMed
description BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocytes and cell growth. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12) and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p = 0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p = 0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71, 7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001, 4.11] ng/ml). CONCLUSIONS: Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-019-5848-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-66201922019-07-22 The difference in serum proteomes in schizophrenia and bipolar disorder Smirnova, Liudmila Seregin, Alexander Boksha, Irina Dmitrieva, Elena Simutkin, German Kornetova, Elena Savushkina, Olga Letova, Anastasia Bokhan, Nikolay Ivanova, Svetlana Zgoda, Victor BMC Genomics Research BACKGROUND: Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). RESULTS: Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism. Protein set in BD was mostly associated with immune response, regulating transport processes across cell membrane and cell communication, development of neurons and oligodendrocytes and cell growth. Concentrations of ankyrin repeat domain-containing protein 12 (ANKRD12) and cadherin 5 in serum samples were determined by ELISA. Significant difference between three groups was revealed in ANKRD12 concentration (p = 0.02), with maximum elevation of ANKRD12 concentration (median level) in schizophrenia followed by BD. Cadherin 5 concentration differed significantly (p = 0.035) between schizophrenic patients with prevailing positive symptoms (4.78 [2.71, 7.12] ng/ml) and those with prevailing negative symptoms (1.86 [0.001, 4.11] ng/ml). CONCLUSIONS: Our results are presumably useful for discovering the new pathways involved in endogenous psychotic disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-019-5848-1) contains supplementary material, which is available to authorized users. BioMed Central 2019-07-11 /pmc/articles/PMC6620192/ /pubmed/31291891 http://dx.doi.org/10.1186/s12864-019-5848-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Smirnova, Liudmila
Seregin, Alexander
Boksha, Irina
Dmitrieva, Elena
Simutkin, German
Kornetova, Elena
Savushkina, Olga
Letova, Anastasia
Bokhan, Nikolay
Ivanova, Svetlana
Zgoda, Victor
The difference in serum proteomes in schizophrenia and bipolar disorder
title The difference in serum proteomes in schizophrenia and bipolar disorder
title_full The difference in serum proteomes in schizophrenia and bipolar disorder
title_fullStr The difference in serum proteomes in schizophrenia and bipolar disorder
title_full_unstemmed The difference in serum proteomes in schizophrenia and bipolar disorder
title_short The difference in serum proteomes in schizophrenia and bipolar disorder
title_sort difference in serum proteomes in schizophrenia and bipolar disorder
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620192/
https://www.ncbi.nlm.nih.gov/pubmed/31291891
http://dx.doi.org/10.1186/s12864-019-5848-1
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