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Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries
PURPOSE: Little is known about the quality of life following pulmonary embolism (PE). The aim of the study was to assess the 12-month illness burden in terms of health-related quality of life (HrQoL) and mortality, in relation to differences in patient characteristics. METHODS: The PREFER in VTE reg...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620245/ https://www.ncbi.nlm.nih.gov/pubmed/30949836 http://dx.doi.org/10.1007/s11136-019-02175-z |
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author | Chuang, Ling-Hsiang Gumbs, Pearl van Hout, Ben Agnelli, Giancarlo Kroep, Sonja Monreal, Manuel Bauersachs, Rupert Willich, Stephen N. Gitt, Anselm Mismetti, Patrick Cohen, Alexander Jimenez, David |
author_facet | Chuang, Ling-Hsiang Gumbs, Pearl van Hout, Ben Agnelli, Giancarlo Kroep, Sonja Monreal, Manuel Bauersachs, Rupert Willich, Stephen N. Gitt, Anselm Mismetti, Patrick Cohen, Alexander Jimenez, David |
author_sort | Chuang, Ling-Hsiang |
collection | PubMed |
description | PURPOSE: Little is known about the quality of life following pulmonary embolism (PE). The aim of the study was to assess the 12-month illness burden in terms of health-related quality of life (HrQoL) and mortality, in relation to differences in patient characteristics. METHODS: The PREFER in VTE registry, a prospective, observational study conducted in seven European countries, was used. Within 2 weeks following an acute symptomatic PE, patients were recruited and followed up for 12 months. Associations between patient characteristics and HrQoL (EQ-5D-5L) and mortality were examined using a regression approach. RESULTS: Among 1399 PE patients, the EQ-5D-5L index score at baseline was 0.712 (SD 0.265), which among survivors gradually improved to 0.835 (0.212) at 12 months. For those patients with and without active cancer, the average index score at baseline was 0.658 (0.275) and 0.717 (0.264), respectively. Age and previous stroke were significant factors for predicting index scores in those with/without active cancer. Bleeding events but not recurrences had a noticeable impact on the HrQoL of patients without active cancer. The 12-month mortality rate post-acute period was 8.1%, ranging from 1.4% in Germany, Switzerland, and Austria to 16.8% in Italy. Mortality differed between patients with active cancer and those without (42.7% vs. 4.7%). CONCLUSION: PE is associated with a substantial decrease in HrQoL at baseline which normalizes following treatment. PE is associated with a high mortality rate especially in patients with cancer, with significant country variation. Bleeding events, in particular, impact the burden of PE. |
format | Online Article Text |
id | pubmed-6620245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-66202452019-07-28 Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries Chuang, Ling-Hsiang Gumbs, Pearl van Hout, Ben Agnelli, Giancarlo Kroep, Sonja Monreal, Manuel Bauersachs, Rupert Willich, Stephen N. Gitt, Anselm Mismetti, Patrick Cohen, Alexander Jimenez, David Qual Life Res Article PURPOSE: Little is known about the quality of life following pulmonary embolism (PE). The aim of the study was to assess the 12-month illness burden in terms of health-related quality of life (HrQoL) and mortality, in relation to differences in patient characteristics. METHODS: The PREFER in VTE registry, a prospective, observational study conducted in seven European countries, was used. Within 2 weeks following an acute symptomatic PE, patients were recruited and followed up for 12 months. Associations between patient characteristics and HrQoL (EQ-5D-5L) and mortality were examined using a regression approach. RESULTS: Among 1399 PE patients, the EQ-5D-5L index score at baseline was 0.712 (SD 0.265), which among survivors gradually improved to 0.835 (0.212) at 12 months. For those patients with and without active cancer, the average index score at baseline was 0.658 (0.275) and 0.717 (0.264), respectively. Age and previous stroke were significant factors for predicting index scores in those with/without active cancer. Bleeding events but not recurrences had a noticeable impact on the HrQoL of patients without active cancer. The 12-month mortality rate post-acute period was 8.1%, ranging from 1.4% in Germany, Switzerland, and Austria to 16.8% in Italy. Mortality differed between patients with active cancer and those without (42.7% vs. 4.7%). CONCLUSION: PE is associated with a substantial decrease in HrQoL at baseline which normalizes following treatment. PE is associated with a high mortality rate especially in patients with cancer, with significant country variation. Bleeding events, in particular, impact the burden of PE. Springer International Publishing 2019-04-04 2019 /pmc/articles/PMC6620245/ /pubmed/30949836 http://dx.doi.org/10.1007/s11136-019-02175-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Chuang, Ling-Hsiang Gumbs, Pearl van Hout, Ben Agnelli, Giancarlo Kroep, Sonja Monreal, Manuel Bauersachs, Rupert Willich, Stephen N. Gitt, Anselm Mismetti, Patrick Cohen, Alexander Jimenez, David Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title | Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title_full | Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title_fullStr | Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title_full_unstemmed | Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title_short | Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries |
title_sort | health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven european countries |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620245/ https://www.ncbi.nlm.nih.gov/pubmed/30949836 http://dx.doi.org/10.1007/s11136-019-02175-z |
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